Technology Process of 17,19-Dihydroxy-1-(1-oxopropyl)aspidospermidin-21-oic acid γ-lactone
There total 8 articles about 17,19-Dihydroxy-1-(1-oxopropyl)aspidospermidin-21-oic acid γ-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trichloride; tetra-(n-butyl)ammonium iodide;
In
dichloromethane;
at -78 - 20 ℃;
for 4.66667h;
DOI:10.1016/j.tet.2012.10.060
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate / methanol / 2.17 h / -78 - 0 °C
2.1: 7 h / 20 °C
3.1: sodium hydroxide / methanol / 7.5 h / 20 - 50 °C
3.2: pH 6 - 7
4.1: potassium hexacyanoferrate(III); sodium hydrogencarbonate / water; tert-butyl alcohol / 0.67 h / 20 °C
4.2: pH 6 - 7
5.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 4.67 h / -78 - 20 °C
With
sodium tetrahydroborate; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium hydroxide; potassium hexacyanoferrate(III);
In
methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tet.2012.10.060
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: benzene / 24 h / Reflux
2.1: acetic acid / 1.5 h / 95 °C
3.1: sodium tetrahydroborate / methanol / 2.17 h / -78 - 0 °C
4.1: 7 h / 20 °C
5.1: sodium hydroxide / methanol / 7.5 h / 20 - 50 °C
5.2: pH 6 - 7
6.1: potassium hexacyanoferrate(III); sodium hydrogencarbonate / water; tert-butyl alcohol / 0.67 h / 20 °C
6.2: pH 6 - 7
7.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 4.67 h / -78 - 20 °C
With
sodium tetrahydroborate; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium hydroxide; potassium hexacyanoferrate(III);
In
methanol; dichloromethane; water; acetic acid; tert-butyl alcohol; benzene;
2.1: |Fischer Indole Synthesis;
DOI:10.1016/j.tet.2012.10.060
