18312-46-4

Basic information

• Product Name: (2-METHOXY-PHENYL)-HYDRAZINE
• Synonyms: (2-METHOXY-PHENYL)-HYDRAZINE;TIMTEC-BB SBB001582;o-Anisylhydrazine
• CAS NO: 18312-46-4
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.17
• Mol File: 18312-46-4.mol

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 263.5±23.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• Solubility: DMSO (Slightly), Methanol (Very Slightly)
• PKA: 5.10±0.10(Predicted)
• CAS DataBase Reference: (2-METHOXY-PHENYL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-METHOXY-PHENYL)-HYDRAZINE(18312-46-4)
• EPA Substance Registry System: (2-METHOXY-PHENYL)-HYDRAZINE(18312-46-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 18312-46-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-METHOXY-PHENYL)-HYDRAZINE is used as an intermediate in the synthesis of biologically active compounds for the development of new drugs. It plays a crucial role in the creation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles, which are known inhibitors of the transforming growth factor β type 1 receptor (ALK5). These inhibitors have potential applications in treating various diseases, including cancer, by targeting and modulating specific cellular signaling pathways.
Used in Chemical Industry:
In the chemical industry, (2-METHOXY-PHENYL)-HYDRAZINE can be utilized as a building block for the synthesis of a wide range of organic compounds with diverse applications. Its unique structure allows for further functionalization and modification, making it a valuable component in the development of new materials and chemicals for various purposes, such as agrochemicals, dyes, and other specialty chemicals.

Upstream product

• 3425-23-8 2-methoxybenzenediazonium chloride 
• 90-04-0 2-methoxy-phenylamine 
• 93-26-5 2-methoxyacetanilide 
• 154419-05-3 Acetic acid N'-cyclohexylidene-N-(2-methoxy-phenyl)-hydrazide 

Downstream Products

• 79984-63-7 N'-(2-methoxyphenyl)acetohydrazide 
• 5099-02-5 2-(2-Methoxy-phenylazo)-[1]naphthol 
• 93139-14-1 tert-butyl 2-(2-methoxyphenyl)hydrazine-1-carboxylate 
• 65078-20-8 o-methoxyphenyl thiosemicarbazide 
• 57369-81-0 3-[(2-methoxy-phenylhydrazono)-methyl]-rifamycin 
• 40887-56-7 N'-(2-Methoxy-phenyl)-hydrazinecarboxylic acid 2-butyl-hexyl ester 
• 24519-71-9 6-(2-methoxy-anilino)-2,3-dihydro-[1,4]dithiino[2,3-c]pyrrole-5,7-dione 
• 34159-01-8 deoxybenzoin o-methoxyphenylhydrazone 
• 53526-99-1 2-<2-(2-methoxyphenyl)hydrazino>tropone 
• 118458-41-6 5,6-Bis-[(2-methoxy-phenyl)-hydrazono]-hexahydro-isoindole-1,3-dione 
• 125160-74-9 N-tosyl-7-methoxy-tryptamine 
• 103286-15-3 7-carboxy-2-(o-methoxyphenyl)-1(2H)-phthalazinone 
• 15992-64-0 6-<2-Methoxy-phenylazo>-5-hydroxy-chrysen 
• 20442-97-1 2-methoxylphenyl azide 

Relevant articles and documents

Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

Production of monoacylhydrazine phenylpropionic

The invention provides a method for producing phenylhydrazine (II), and the method has excellent yields. More specifically, the invention provides a method for producing phenylhydrazine which comprises the following steps: diazonium salt (I) is reacted wi

Synthesis and Site-Specific Incorporation of Red-Shifted Azobenzene Amino Acids into Proteins

A series of red-shifted azobenzene amino acids were synthesized in moderate-to-excellent yields via a two-step procedure in which tyrosine derivatives were first oxidized to the corresponding quinonoidal spirolactones followed by ceric ammonium nitrate-catalyzed azo formation with the substituted phenylhydrazines. The resulting azobenzene-alanine derivatives exhibited efficient trans/cis photoswitching upon irradiation with a blue (448 nm) or green (530 nm) LED light. Moreover, nine superfolder green fluorescent protein (sfGFP) mutants carrying the azobenzene-alanine analogues were expressed in E. coli in good yields via amber codon suppression with an orthogonal tRNA/PylRS pair, and one of the mutants showed durable photoswitching with the LED light.

Phenylpropionic purification of β-hydroxyphenylalkanecarboxylate compd. alkylhydrazine-

The invention provides a method for purifying a phenylhydrazine-beta-carboxylic ester compound, wherein chloroaniline compounds (II) in the crude product of the phenylhydrazine-beta-carboxylic ester compound (I) can be effectively separated and removed, w

Reduction of hydrazines to amines with aqueous solution of titanium(iii) trichloride

N-N bond cleavage in hydrazines is widely used in the preparation of amines and thus occupies a significant place in organic synthesis. In this paper, we report a new method for the reductive cleavage of N-N bonds in hydrazines by commercially available and cheap aqueous titanium(iii) trichloride. The reaction proceeds smoothly under a broad pH range from acidic to neutral and basic conditions to afford amines in good yields. This method is compatible with substrates containing functionalities such as C-C double bonds, benzyl-nitrogen bonds, benzyloxy and acyl groups. The Royal Society of Chemistry 2011.

Acid and base stable diphenylmethanol derivatives and methods of use

The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.

AMINATIONS WITH OXAZIRIDINES - SYNTHESES OF ARYL- AND HETARYL-HYDRAZINES

Five acetylaminobenzenes (2) (X=CH), two 3-acetylaminopyridines (2) (X=N) and one 3-acetylaminopyridine-1-oxide (2) (X=N(O)) are aminated by 1-oxa-2-azaspirooctane (1) / DABCO to cyclohexylidenehydrazino compounds (3), which are characterized as benz