L-Leucine, N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9 -yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Leucine, N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9 -yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl ester
CAS No.:93962-35-7
Molecular Formula:C₄₆H₆₂N₄O₉S
Molecular Weight:847.086
Hs Code.:

L-Leucine,
N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9
-yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl
ester

Synonyms:

Suppliers and Price of L-Leucine, N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9 -yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Leucine, N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9 -yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl ester

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Technology Process of L-Leucine, N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9 -yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl ester

There total 12 articles about L-Leucine, N-[N-[N-[N-[[[2,7-bis(1,1-dimethylethyl)-10,10-dioxido-9H-thioxanthen-9 -yl]methoxy]carbonyl]glycyl]glycyl]-L-phenylalanyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123168-16-1
Chlorocarbonylmethyl-carbamic acid 2,7-di-tert-butyl-10,10-dioxo-9,10-dihydro-10λ⁶-thioxanthen-9-ylmethyl ester

: 82362-19-4
Gly-Phe-Leu(t-Bu)

: 93962-35-7
(S)-2-((S)-2-{2-[2-(2,7-Di-tert-butyl-10,10-dioxo-9,10-dihydro-10λ⁶-thioxanthen-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jo00286a019

Reference yield:

: 139-66-2
diphenyl sulfide

: 93962-35-7
(S)-2-((S)-2-{2-[2-(2,7-Di-tert-butyl-10,10-dioxo-9,10-dihydro-10λ⁶-thioxanthen-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / ferric chloride / CH₂Cl₂ / 72 h / Heating

2: 37 percent / tin(IV) chloride / CH₂Cl₂ / 12 h / Ambient temperature

3: 1.) n-butyllithium / 1.) THF, -75 deg C, 30 min, 2.) reflux, 30 min

4: 55 percent / 30percent H₂O₂, acetic acid / 4 h / 100 °C

5: 87 percent / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temperature, 4 h

6: 10percent aq. NaHCO₃ / tetrahydrofuran / 0.33 h / 0 °C

7: CF₃COOH / CH₂Cl₂ / Ambient temperature

8: 72 percent / thionyl chloride / CH₂Cl₂ / 0.5 h / Heating

9: 10percent aq. NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

With n-butyllithium; thionyl chloride; dihydrogen peroxide; iron(III) chloride; tin(IV) chloride; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00286a019

Reference yield:

: 52908-55-1
bis(4-tert-butylphenyl) sulfide

: 93962-35-7
(S)-2-((S)-2-{2-[2-(2,7-Di-tert-butyl-10,10-dioxo-9,10-dihydro-10λ⁶-thioxanthen-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 37 percent / tin(IV) chloride / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) n-butyllithium / 1.) THF, -75 deg C, 30 min, 2.) reflux, 30 min

3: 55 percent / 30percent H₂O₂, acetic acid / 4 h / 100 °C

4: 87 percent / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temperature, 4 h

5: 10percent aq. NaHCO₃ / tetrahydrofuran / 0.33 h / 0 °C

6: CF₃COOH / CH₂Cl₂ / Ambient temperature

7: 72 percent / thionyl chloride / CH₂Cl₂ / 0.5 h / Heating

8: 10percent aq. NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

With n-butyllithium; thionyl chloride; dihydrogen peroxide; tin(IV) chloride; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00286a019