5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

Base Information

Chemical Name:5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester
CAS No.:37778-51-1
Molecular Formula:C₁₀H₁₅NO₃
Molecular Weight:197.234
Hs Code.:
Mol file:37778-51-1.mol

Synonyms:2-Azabicyclo[2.2.2]octane-2-carboxylic acid,5-oxo-,ethyl ester;N-Carbethoxydioscoron;5-Oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid ethyl ester;(+-)-2-Ethoxycarbonyl-2-azabicyclo<2.2.2>octan-5-on;N-ethoxycarbonyl-2-azabicyclo<2.2.2>octan-5-one;2-Ethoxycarbonyl-2-azabicyclo[2.2.2]octan-5-one;

Suppliers and Price of 5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 5-oxo-2-azabicyclo[2.2.2]octane-2-carboxylate
5g
$ 2250.00

Matrix Scientific
Ethyl 5-oxo-2-azabicyclo[2.2.2]octane-2-carboxylate
1g
$ 900.00

Total 3 raw suppliers

Chemical Property of 5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

Chemical Property:

Vapor Pressure:0.00057mmHg at 25°C
Boiling Point:311.3°Cat760mmHg
Flash Point:142.1°C
PSA：46.61000
Density:1.198g/cm³
LogP:1.13420

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 5-oxo-2-azabicyclo[2.2.2]octane-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

There total 4 articles about 5-Oxo-2-azabicyclo[2.2.2]octane-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2-azabicyclo[2.2.2]octan-5-one hydrochloride salt

: 541-41-3
chloroformic acid ethyl ester

: 37778-51-1
5-Oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 71.0%

: 2-azabicyclo[2.2.2]octan-5-one trifluoroacetate

: 541-41-3
chloroformic acid ethyl ester

: 37778-51-1
5-Oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

Guidance literature:: 2-azabicyclo[2.2.2]octan-5-one trifluoroacetate; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

chloroformic acid ethyl ester; In dichloromethane; at 0 - 27 ℃; for 2h; Inert atmosphere;

Reference yield:

: 617714-22-4,1932043-29-2
tert-butyl 5-oxo-2-azabicyclo[2.2.2]octane-2-carboxylate

: 37778-51-1
5-Oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 3 h / 20 - 27 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 27 °C / Inert atmosphere

With triethylamine; In dichloromethane;