Technology Process of Ethyl 3-(chloromethyl)pyridine-2-carboxylate
There total 4 articles about Ethyl 3-(chloromethyl)pyridine-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-chloro-succinimide; 2,2'-azobis(isobutyronitrile);
In
tetrachloromethane; acetic acid;
at 60 ℃;
Irradiation;
chlorinated reagent was added during 8 h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 24 g / dimethyl sulphate / H2O / 5 h / 80 °C
2: sodium hydroxide, water / 4 h / Heating
3: 70 percent / hydrogen chloride (gas) / 4 h / Heating
4: N-chlorosuccinimide, azobisisobutyronitrile / acetic acid; CCl4 / 60 °C / Irradiation; chlorinated reagent was added during 8 h
With
hydrogenchloride; sodium hydroxide; N-chloro-succinimide; 2,2'-azobis(isobutyronitrile); water; dimethyl sulfate;
In
tetrachloromethane; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide, water / 4 h / Heating
2: 70 percent / hydrogen chloride (gas) / 4 h / Heating
3: N-chlorosuccinimide, azobisisobutyronitrile / acetic acid; CCl4 / 60 °C / Irradiation; chlorinated reagent was added during 8 h
With
hydrogenchloride; sodium hydroxide; N-chloro-succinimide; 2,2'-azobis(isobutyronitrile); water;
In
tetrachloromethane; acetic acid;
