Benzeneacetonitrile, a-hydroxy-4-methoxy-a-(trifluoromethyl)-

Base Information

• Chemical Name: Benzeneacetonitrile, a-hydroxy-4-methoxy-a-(trifluoromethyl)-
• CAS No.: 94083-89-3
• Molecular Formula: C10H8F3NO2
• Molecular Weight: 231.174
• Mol file: 94083-89-3.mol

Synonyms:

Chemical Property of Benzeneacetonitrile, a-hydroxy-4-methoxy-a-(trifluoromethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetonitrile, a-hydroxy-4-methoxy-a-(trifluoromethyl)-

There total 1 articles about Benzeneacetonitrile, a-hydroxy-4-methoxy-a-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trimethylsilyl cyanide (7677-24-9) + 4'-methoxy-2,2,2-trifluoroacetophenone (711-38-6) → 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionitrile (94083-89-3)

Guidance literature:

trimethylsilyl cyanide; 4'-methoxy-2,2,2-trifluoroacetophenone; With potassium cyanide; 18-crown-6 ether; In dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2003.12.011

Reference yield: 99.0%

3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionitrile (94083-89-3) → 3,3,3-trifluoro-2-hydroxy-2-(4-methoxy-phenyl)-propionamide

Guidance literature:

3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionitrile; With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 0.75h;

In 1,4-dioxane; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2003.12.011

upstream raw materials:

trimethylsilyl cyanide

4'-methoxy-2,2,2-trifluoroacetophenone

Refernces

• 1、 Kiyooka, Syun-ichi,Fujiyama, Ryoji,Kawaguchi, Katsuhiko. "ONE-POT SYNTHESIS OF α-CHLORONITRILES FROM ARYLCARBONYL COMPOUNDS". . p. 1979 - 1980. Retrieved 2007/10/02.