N-(N(sup 2)-((6,7-Dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)glycine

Base Information

Chemical Name:N-(N(sup 2)-((6,7-Dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)glycine
CAS No.:66935-36-2
Molecular Formula:C23H33N5O8S
Molecular Weight:539.6018
Hs Code.:
DSSTox Substance ID:DTXSID30985614

Synonyms:N(alpha)-(6,7-dimethoxynaphthalene-2-sulfonyl)-L-Arg-N-(2-methoxyethyl)-Gly;No. 407

Suppliers and Price of N-(N(sup 2)-((6,7-Dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-(N(sup 2)-((6,7-Dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)glycine

Chemical Property:

Vapor Pressure:8.31E-27mmHg at 25°C
Boiling Point:797.2°Cat760mmHg
Flash Point:435.9°C
PSA：97.77000
Density:1.39g/cm³
LogP:0.66090
XLogP3:0.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:15
Exact Mass:539.20498420
Heavy Atom Count:37
Complexity:877

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COCCN(CC(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C1=CC2=CC(=C(C=C2C=C1)OC)OC
Isomeric SMILES:COCCN(CC(=O)O)C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC2=CC(=C(C=C2C=C1)OC)OC

Technology Process of N-(N(sup 2)-((6,7-Dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)glycine

There total 6 articles about N-(N(sup 2)-((6,7-Dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 66935-35-1
N₂-(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-methoxyethyl)glycine ethyl ester

: 66935-36-2
N^α-(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-methoxyethyl)glycine

Guidance literature:: With sodium hydroxide; In ethanol; for 30h; Ambient temperature;
DOI:10.1021/jm00186a003

Reference yield:

: 74-79-3,25212-18-4
L-arginine

: 66935-36-2
N^α-(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-methoxyethyl)glycine

Guidance literature:: Multi-step reaction with 4 steps

1: 71.6 percent / K₂CO₃ / H₂O; benzene / 3 h / 60 °C

2: SOCl₂, DMF / 4 h / Ambient temperature

3: 91 percent / Et₃N / CHCl₃ / 3 h / Ambient temperature

4: 72 percent / 1 N NaOH / ethanol / 30 h / Ambient temperature

With sodium hydroxide; thionyl chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In ethanol; chloroform; water; benzene;
DOI:10.1021/jm00186a003

Reference yield:

: 63093-17-4
2-(6,7-Dimethoxynaphthalenyl)sulfonyl chloride

: 66935-36-2
N^α-(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-methoxyethyl)glycine

Guidance literature:: Multi-step reaction with 4 steps

1: 71.6 percent / K₂CO₃ / H₂O; benzene / 3 h / 60 °C

2: SOCl₂, DMF / 4 h / Ambient temperature

3: 91 percent / Et₃N / CHCl₃ / 3 h / Ambient temperature

4: 72 percent / 1 N NaOH / ethanol / 30 h / Ambient temperature

With sodium hydroxide; thionyl chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In ethanol; chloroform; water; benzene;
DOI:10.1021/jm00186a003