2,4-Dichlorobenzaldehyde

Base Information

• Chemical Name: 2,4-Dichlorobenzaldehyde
• CAS No.: 874-42-0
• Molecular Formula: C7H4Cl2O
• Molecular Weight: 175.014
• Hs Code.: 29130000
• European Community (EC) Number: 212-861-1
• NSC Number: 8762
• UN Number: 3261
• UNII: Z08QL2124R
• DSSTox Substance ID: DTXSID1022130
• Nikkaji Number: J30.720C
• Wikidata: Q27294829
• ChEMBL ID: CHEMBL1531235
• Mol file: 874-42-0.mol

Synonyms:2,4-DICHLOROBENZALDEHYDE;874-42-0;Benzaldehyde, 2,4-dichloro-;CCRIS 6013;NSC 8762;EINECS 212-861-1;MFCD00003305;2,4-dichloro benzaldehyde;2,4-dichloro-benzaldehyde;UNII-Z08QL2124R;AI3-16063;DTXSID1022130;Z08QL2124R;NSC-8762;NSC8762;2,4 dichloro benzaldehyde;2,4-di-chlorobenzaldehyde;SCHEMBL95435;O,P-DICHLOROBENZALDEHYDE;2,4-bis(chloranyl)benzaldehyde;DTXCID302130;CHEMBL1531235;2,4-Dichlorobenzaldehyde, 99%;(2,4-dichloro-phenyl)-methanone;(2,4-dichlorophenyl)formaldehyde;AMY39072;DICHLOROBENZALDEHYDE, 2,4-;Tox21_201217;STK299308;AKOS000118972;CS-W017473;LS-1876;PS-6004;2,4-DICHLOROPHENYLCARBOXALDEHYDE;NCGC00091704-01;NCGC00091704-02;NCGC00258769-01;AC-11246;CAS-874-42-0;D0330;FT-0610037;EN300-18374;D71088;A842216;AH-034/32850055;W-104022;Q27294829;Z57127525;F2190-0604

Chemical Property of 2,4-Dichlorobenzaldehyde

Chemical Property:

• Appearance/Colour: light yellow to beige crystalline powder, crystals
• Vapor Pressure: 0.0572mmHg at 25°C
• Melting Point: 64-69 °C(lit.)
• Refractive Index: 1.6
• Boiling Point: 233 °C at 760 mmHg
• Flash Point: 100.2 °C
• PSA: 17.07000
• Density: 1.4 g/cm³
• LogP: 2.80590
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive
• Water Solubility.: <0.1 g/100 mL at 24℃
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 173.9639201
• Heavy Atom Count: 10
• Complexity: 127
• Transport DOT Label: Corrosive

Purity/Quality:

≥99% ^*data from raw suppliers

2,4-Dichlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, N, Xi
• Hazard Codes: C,N,Xi
• Statements: 34-51/53-36/37/38
• Safety Statements: 26-36/37/39-45-61-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)C=O
• Uses: 2,4-Dichlorobenzaldehyde is used in the synthesis of platelet aggregation inhibitors. Also used in the preparation of novel Schiff bases containing quinazolinone rings. 2,4-Dichlorobenzaldehyde was used in the solid-phase synthesis of a series of indole-based peptoids.

Technology Process of 2,4-Dichlorobenzaldehyde

There total 67 articles about 2,4-Dichlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-dichlorobenzaldoxime (56843-28-8) → 2,4-dichlorobenzaldeyhde (874-42-0)

Guidance literature:

With potassium permanganate; 1-n-butyl-3-methylimidazolim bromide; at 20 ℃; for 0.166667h; chemoselective reaction; Ionic liquid;

DOI:10.1002/jccs.200900061

Reference yield: 96.0%

C13H20Cl2OSi → 2,4-dichlorobenzaldeyhde (874-42-0)

Guidance literature:

With tetra-N-butylammonium tribromide; In acetonitrile; at 20 ℃; for 8h; Irradiation;

DOI:10.1016/j.jphotochem.2019.112220

Reference yield: 89.0%

2,4-dichlorobenzoyl chloride (89-75-8) → 2,4-dichlorobenzaldeyhde (874-42-0)

Guidance literature:

With triethylsilane; iron(III)-acetylacetonate; at 40 - 50 ℃; for 1h;

upstream raw materials:

2,4-dichloro-1-(dibromomethyl)benzene

1-pyrrolidinecarboxaldehyde

2-bromocyclohexane-1,3-dienone

4-morpholinecarboxaldehyde

Downstream raw materials:

2-(2,4-dichloro-phenyl)-2-hydroxy-1-pyrrol-2-yl-ethanone

3t-(2,4-dichloro-phenyl)-1-[2]thienyl-propenone

5-(2,4-dichloro-benzylidene)-imidazolidine-2,4-dione

N'-[(E)-(2,4-dichloro-phenyl)methylidene]isonicotinohydrazide

Refernces

Synthesis, characterization and catalytic activity of three palladium(II) complexes containing Schiff base ligands

10.1007/s11243-012-9635-y

The research focuses on the synthesis, characterization, and catalytic activity of three palladium(II) complexes containing Schiff base ligands. The purpose of this study was to create new Pd(II) complexes that could serve as heterogeneous catalysts in organic reactions, specifically in the Heck coupling reaction of bromobenzene with acrylic acid. The researchers synthesized three new Pd(II) complexes: [Pd4(L1)4] (1), [Pd2(L2)2Cl2] (2), and [Pd(L3)2Cl2] (3), using solvothermal methods. The Schiff base ligands, HL1, L2, and L3, were prepared by condensation reactions involving benzaldehyde or 2,4-dichlorobenzaldehyde with aromatic amines. The palladium complexes were then formed by reacting PdCl2 with these ligands under solvothermal conditions. The study concluded that these complexes show moderate catalytic activity in the Heck coupling reaction, and their effectiveness is sensitive to the choice of base and solvent. The chemicals used in the process included palladium chloride, methanol, ethanol, and various aromatic amines and aldehydes for the preparation of the Schiff base ligands, as well as bromobenzene, acrylic acid, and triethylamine for the catalytic reactions.