56843-28-8

Basic information

• Product Name: 2,4-DICHLOROBENZALDEHYDE OXIME
• Synonyms: AKOS B004067;2,4-DICHLOROBENZALDEHYDE OXIME;2,4-DICHLOROBENZALDOXIME;2,4-dichloro-benzaldehydoxime
• CAS NO: 56843-28-8
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.03
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 56843-28-8.mol
• Article Data: 32

Chemical Properties

• Melting Point: 134℃
• Boiling Point: 271.3°Cat760mmHg
• Flash Point: 117.9°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 0.00319mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 2,4-DICHLOROBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROBENZALDEHYDE OXIME(56843-28-8)
• EPA Substance Registry System: 2,4-DICHLOROBENZALDEHYDE OXIME(56843-28-8)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 56843-28-8(Hazardous Substances Data)

Usage

General Description

2,4-Dichlorobenzaldehyde oxime is a chemical compound with the molecular formula C7H5Cl2NO. It is primarily used as a reagent in organic synthesis, particularly in the formation of hydrazones and in the synthesis of pharmaceutical intermediates. 2,4-DICHLOROBENZALDEHYDE OXIME is known for its ability to undergo various chemical reactions, including cyclization, condensation, and oxidation. Its structure consists of a benzene ring substituted with two chlorine atoms and an aldehyde functional group attached to an oxime group. 2,4-Dichlorobenzaldehyde oxime is considered a versatile reagent in the field of organic chemistry, offering a range of potential applications. However, it is important to handle this compound with care, as prolonged exposure or ingestion can have harmful effects on human health.

InChI:InChI=1/C7H5Cl2NO/c8-6-2-1-5(4-10-11)7(9)3-6/h1-4,11H/b10-4+

Upstream product

• 391200-38-7 2-((2,4-dichlorobenzyl)oxy)tetrahydro-2H-pyran 
• 624286-51-7 2,4-dichlorobenzyl trimethysilyl ether 
• 95-73-8 2,4-dichlorotoluene 
• 95-00-1 2,4-dichloro-benzenemethanamine 
• 30866-46-7 N'-(2,4-dichlorobenzylidene)-2-iminochromen-3-carbohydrazide 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 29203-60-9 2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride 
• 61101-18-6 4-[1-(2,4-Dichloro-phenyl)-meth-(Z)-ylideneaminooxy]-3-nitro-benzoic acid methyl ester 
• 70-55-3 toluene-4-sulfonamide 
• 2621-67-2 methyl N-(2,4-dichlorophenyl)carbamate 
• 325744-54-5 C₁₀H₆Cl₃NO 
• 2775-38-4 2,4-dichlorothiobenzamide 
• 1191938-75-6 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[1-(2,4-dichloro-phenyl)-meth-(E)-ylideneaminooxy]-1-methyl-ethyl}-amide 
• 128671-84-1 3-(2,4-Dichloro-phenyl)-4-formyl-1,1-diphenyl-2,4a,5,6-tetrahydro-1H-[2]pyrindine-5,6-dicarboxylic acid dimethyl ester 
• 138535-70-3 (3aR,5S,6S,6aR)-5-[(S)-3-(2,4-Dichloro-phenyl)-4,5-dihydro-isoxazol-5-yl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 
• 138535-70-3 3-(2,4-dichlorophenyl)-5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-2-isoxazoline 
• 54696-53-6 3,4-di-(2,4-dichlorophenyl)furoxan 
• 159693-19-3 5-(Chloro-difluoro-methyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester 
• 159693-11-5 3-(2,4-Dichloro-phenyl)-5-trifluoromethyl-isoxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and SAR study of simple aryl oximes and nitrofuranyl derivatives with potent activity against Mycobacterium tuberculosis

Background: Oximes and nitrofuranyl derivatives are particularly important compounds in medicinal chemistry. Thus, many researchers have been reported to possess antibacterial, antiparasitic, insecticidal and fungicidal activities. Methods: In this work, we report the synthesis and the biological activity against Mycobacterium tuberculosis H37RV of a series of fifty aryl oximes, ArCH=N-OH, I, and eight nitrofuranyl compounds, 2-nitrofuranyl-X, II. Results: Among the oximes, I: Ar = 2-OH-4-OH, 42, and I: Ar = 5-nitrofuranyl, 46, possessed the best activity at 3.74 and 32.0 μM, respectively. Also, 46, the nitrofuran compounds, II; X = MeO, 55, and II: X = NHCH2Ph, 58, (14.6 and 12.6 μM, respectively), exhibited excellent biological activities and were non-cytotoxic. Conclusion: The compound 55 showed a selectivity index of 9.85. Further antibacterial tests were performed with compound 55 which was inactive against Enterococcus faecalis, Klebisiella pneumonae, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhymurium and Shigel-la flexneri. This study adds important information to the rational design of new lead anti-TB drugs. Structure-activity Relationship (SAR) is reported.

Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus

Antibiotic resistance among clinically significant bacterial pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) is becoming a prevalent threat to public health, and new antibacterial agents with novel mechanisms of action hence are in an urgent need. As a part of continuing effort to develop antibacterial agents, we rationally designed and synthesized two series of 4,5-dihydroisoxazol-5-yl and 4,5-dihydroisoxazol-3-yl-containing benzamide derivatives that targeted the bacterial cell division protein FtsZ. Evaluation of their activity against a panel of Gram-positive and -negative pathogens revealed that compound A16 possessing the 4,5-dihydroisoxazol-5-yl group showed outstanding antibacterial activity (MIC, ≤0.125–0.5 μg/mL) against various testing strains, including methicillin-resistant, penicillin-resistant and clinical isolated S. aureus strains. Besides, further mouse infection model revealed that A16 could be effective in vivo and non-toxic to Hela cells. Finally, a detailed discussion of structure-activity relationships was conducted, referring to the docking results. It is worth noting that substituting a 4,5-dihydroisoxazole ring for the isoxazole ring not only broadened the antibacterial spectrum but also resulted in a significant increase in antibacterial activity against S. aureus strains. Taken together, these results suggest a promising chemotype for the development of new FtsZ-targeting bactericidal agents.

COMPOUNDS FOR MODULATING FXR

Provided herein are compounds of Formula (I), a stereoisomer, enantiomer or a pharmaceutically acceptable salt thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).