Methylprednisolone aceponate

Base Information

Chemical Name:Methylprednisolone aceponate
CAS No.:86401-95-8
Molecular Formula:C27H36O7
Molecular Weight:472.579
Hs Code.:
European Community (EC) Number:658-084-5,687-724-6
UNII:ET54W9J4U2
DSSTox Substance ID:DTXSID2023301
Nikkaji Number:J25.810E
Wikipedia:Methylprednisolone_aceponate
Wikidata:Q6824052
NCI Thesaurus Code:C90955
Metabolomics Workbench ID:155003
ChEMBL ID:CHEMBL1697782

Synonyms:6alpha-methylprednisolone aceponate;Advantan;Adventan;Lexxema;methylprednisolone aceponate

Suppliers and Price of Methylprednisolone aceponate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6α-MethylPrednisoloneAceponate
250mg
$ 785.00

Matrix Scientific
Methylprednisolone aceponate 95+%
1g
$ 1647.00

Matrix Scientific
Methylprednisolone aceponate 95+%
250mg
$ 756.00

Crysdot
Methylprednisoloneaceponate 95+%
250mg
$ 79.00

Crysdot
Methylprednisoloneaceponate 95+%
1g
$ 198.00

Crysdot
Methylprednisoloneaceponate 95+%
5g
$ 594.00

Chemenu
(6S,8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylpropionate 95%
1g
$ 204.00

Chemenu
(6S,8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylpropionate 95%
5g
$ 561.00

Biosynth Carbosynth
6a-Methyl prednisolone aceponate
25 mg
$ 300.00

Biosynth Carbosynth
6a-Methyl prednisolone aceponate
10 mg
$ 200.00

Total 115 raw suppliers

Chemical Property of Methylprednisolone aceponate

Chemical Property:

Vapor Pressure:1.11E-16mmHg at 25°C
Refractive Index:1.559
Boiling Point:595.803 °C at 760 mmHg
PKA:14.05±0.70(Predicted)
Flash Point:193.08 °C
PSA：106.97000
Density:1.233 g/cm³
LogP:3.33530
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Ethyl Acetate(Slightly)
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:472.24610348
Heavy Atom Count:34
Complexity:980

Purity/Quality:

99% ^*data from raw suppliers

6α-MethylPrednisoloneAceponate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)OC1(CCC2C1(CC(C3C2CC(C4=CC(=O)C=CC34C)C)O)C)C(=O)COC(=O)C
Isomeric SMILES:CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)C)O)C)C(=O)COC(=O)C
Recent ClinicalTrials:Prevention of Development of Transcutaneous Sensitization in Children With Atopic Dermatitis During Their First Year of Life
Recent EU Clinical Trials:Double-blind, randomised clinical study comparing efficacy and safety of Methylprednisolone Aceponate 0.1% Ointment (Test) vs. Advantan 0.1% Ointment (Reference) vs. Vehicle in patients with mild to moderate atopic dermatitis
Uses Methylprednisolone aceponate used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.

Technology Process of Methylprednisolone aceponate

There total 6 articles about Methylprednisolone aceponate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%