BOC-GLN-OSU

Base Information

• Chemical Name: BOC-GLN-OSU
• CAS No.: 18800-78-7
• Molecular Formula: C14H21 N3 O7
• Molecular Weight: 343.337
• Mol file: 18800-78-7.mol

Synonyms:Carbamicacid, [4-amino-1-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-4-oxobutyl]-,1,1-dimethylethyl ester, (S)-; Succinimide, N-[(N2-carboxy-L-glutaminyl)oxy]-,tert-butyl ester (8CI); Glutamine, N2-carboxy-, N2-tert-butyl ester,succinimido deriv., L-; NSC 334374; tert-Butyloxycarbonyl-L-glutamine,N-hydroxysuccinimide ester

Chemical Property of BOC-GLN-OSU

Chemical Property:

• Melting Point: 121-124 °C (dec.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 145.10000
• Density: 1.33g/cm³
• LogP: 0.78150
• Storage Temp.: −20°C

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-L-glutamine N-hydrosuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of BOC-GLN-OSU

There total 1 articles about BOC-GLN-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Boc-Gln-OH (13726-85-7) → Boc-Gln-ONSu (18800-78-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 4 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2019.126820

Reference yield: 94.0%

Boc-Gln-ONSu (18800-78-7) + H-Phe-Phe-Gly-OH*HCl → N-t-Boc-Gln-Phe-Phe-Gly-OH (64699-00-9)

Guidance literature:

With TEA; In N,N-dimethyl-formamide; 0 deg C 2 h, room temp. 20 h;

Reference yield: 73.0%

Boc-Gln-ONSu (18800-78-7) + H-Asp(Bzl)-Ile-Met-NH-NH-Troc (105220-30-2) → Boc-Gln-Asp(Bzl)-Ile-Met-NH-NH-Troc (105220-28-8)

Guidance literature:

With N-ethylmorpholine;; In N,N-dimethyl-formamide; at 20 ℃; for 150h; pH=7;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Gln-OH

Downstream raw materials:

Boc-Gln-Lys(Z)-OPh

Boc-Gln-Asp(Bzl)-Ile-Met-NH-NH-Troc

N-t-Boc-Gln-Phe-Phe-Gly-OH

(S)-4-Amino-4-(3-phenethyl-[1,2,4]oxadiazol-5-yl)-butyramide

Refernces