Technology Process of 1-Piperidinecarboxylic acid, 3-[(tetrahydro-2H-pyran-2-yl)oxy]-,
phenylmethyl ester, (3S)-
There total 6 articles about 1-Piperidinecarboxylic acid, 3-[(tetrahydro-2H-pyran-2-yl)oxy]-,
phenylmethyl ester, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
Ambient temperature;
DOI:10.1021/jo00206a040
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / lithium aluminum hydride / diethyl ether / 5 h / Heating
2: 93 percent / magnesium oxide / H2O / 3 h / 0 °C
3: 60 percent / 90percent aq. trifluoroacetic acid / 0.08 h / Ambient temperature
4: 80 percent / pyridine / 1.) 0 deg C, 1 h, 2.) 8 deg C, 40 h
5: 100 percent / 4-methylbenzenesulfonic acid / diethyl ether / Ambient temperature
6: 62 percent / sodium hydride / tetrahydrofuran / Ambient temperature
With
pyridine; lithium aluminium tetrahydride; magnesium oxide; sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1021/jo00206a040
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / magnesium oxide / H2O / 3 h / 0 °C
2: 60 percent / 90percent aq. trifluoroacetic acid / 0.08 h / Ambient temperature
3: 80 percent / pyridine / 1.) 0 deg C, 1 h, 2.) 8 deg C, 40 h
4: 100 percent / 4-methylbenzenesulfonic acid / diethyl ether / Ambient temperature
5: 62 percent / sodium hydride / tetrahydrofuran / Ambient temperature
With
pyridine; magnesium oxide; sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1021/jo00206a040
