Benzene, [[1-methyl-2-(2-propenyloxy)ethoxy]methyl]-, (S)-

Base Information

• Chemical Name: Benzene, [[1-methyl-2-(2-propenyloxy)ethoxy]methyl]-, (S)-
• CAS No.: 94985-38-3
• Molecular Formula: C13H18O2
• Molecular Weight: 206.285
• Mol file: 94985-38-3.mol

Synonyms:

Chemical Property of Benzene, [[1-methyl-2-(2-propenyloxy)ethoxy]methyl]-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, [[1-methyl-2-(2-propenyloxy)ethoxy]methyl]-, (S)-

There total 6 articles about Benzene, [[1-methyl-2-(2-propenyloxy)ethoxy]methyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-O-Trityl-3-O-allyl-glycerol (71026-29-4) → 1-O-allyl-2-O-benzyl-3-deoxy-2(S)-glycerol (94985-38-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 16 h / 50 °C

2: camphorsulfonic acid / methanol; tetrahydrofuran / 16 h / 20 °C

3: 5 N sodium methoxide / methanol / 1 h / 20 °C

4: lithium aluminum hydride / toluene; 1,2-dimethoxy-ethane / 4 h

5: 50percent sodium hydride / dimethylformamide; paraffin

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; paraffin;

Reference yield:

(R)-3-allyloxypropane-1,2-diol (123-34-2,73485-54-8,90940-93-5,55941-86-1) → 1-O-allyl-2-O-benzyl-3-deoxy-2(S)-glycerol (94985-38-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 4-dimethylaminopyridine / pyridine / 24 h / 20 °C

2: 16 h / 50 °C

3: camphorsulfonic acid / methanol; tetrahydrofuran / 16 h / 20 °C

4: 5 N sodium methoxide / methanol / 1 h / 20 °C

5: lithium aluminum hydride / toluene; 1,2-dimethoxy-ethane / 4 h

6: 50percent sodium hydride / dimethylformamide; paraffin

With dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium methylate; sodium hydride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; paraffin;

Reference yield:

(S)-4-((allyloxy)methyl)-2,2-dimethyl-1,3-dioxolane (56083-15-9) → 1-O-allyl-2-O-benzyl-3-deoxy-2(S)-glycerol (94985-38-3)

Guidance literature:

Multi-step reaction with 7 steps

1: aq. acetic acid / 1 h / 100 °C

2: 4-dimethylaminopyridine / pyridine / 24 h / 20 °C

3: 16 h / 50 °C

4: camphorsulfonic acid / methanol; tetrahydrofuran / 16 h / 20 °C

5: 5 N sodium methoxide / methanol / 1 h / 20 °C

6: lithium aluminum hydride / toluene; 1,2-dimethoxy-ethane / 4 h

7: 50percent sodium hydride / dimethylformamide; paraffin

With dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium methylate; sodium hydride; acetic acid; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; paraffin;

upstream raw materials:

(+)-(S)-1-(allyloxy)propan-2-ol

benzyl bromide

(S)-1-O-Trityl-3-O-allyl-glycerol

(R)-3-allyloxypropane-1,2-diol

Downstream raw materials:

(S)-2-(benzyloxy)propan-1-ol

2-O-benzyl-1-O-<4-O-<4-O-(β-D-glucopyranosyl)-β-D-glucopyranosyl>-2,3,6-tri-O-benzyl-α-D-glucopyranosyl>-3-deoxy-2(S)-glycerol

1-O-(4-O-acetyl-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-3-deoxy-2(S)-glycerol

2-O-benzyl-1-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-3-deoxy-2(S)-glycerol