10.1021/ja00198a053
The study investigates the design and synthesis of ion-selective chromogenic ionophores for detecting potassium (K+) and sodium (Na+) ions in body fluids. The researchers, led by Donald J. Cram, developed two potassium and one sodium ion-selective chromogenic ionophores (compounds 1-4) that exhibit high sensitivity and selectivity for K+ and Na+ ions. These ionophores are useful for colorimetric assays, allowing for the detection of K+ and Na+ ions in aqueous solutions with detection limits as low as 4 x 10^-6 M for K+ and 2 x 10^-7 M for Na+. The study also explores the influence of pH and solvent composition on the ionophores' selectivity and binding strength. The compounds were synthesized using various aryl compounds as intermediates, and their UV-visible spectral changes in the presence and absence of Na+ and K+ ions were reported. The study highlights the potential of these ionophores for practical applications in clinical and analytical chemistry, particularly in the analysis of serum and other biological fluids.