AMINO-(3-CHLORO-PHENYL)-ACETIC ACID

Base Information

• Chemical Name: AMINO-(3-CHLORO-PHENYL)-ACETIC ACID
• CAS No.: 7292-71-9
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol file: 7292-71-9.mol

Synonyms:Benzeneaceticacid, a-amino-3-chloro-, (?à)-;Glycine, 2-(m-chlorophenyl)-,DL- (8CI);3-Chlorophenylglycine;DL-a-Amino-3-chlorophenylacetic acid;NSC 154922;Amino-(3-chloro-phenyl)-acetic acid;

Chemical Property of AMINO-(3-CHLORO-PHENYL)-ACETIC ACID

Chemical Property:

• Vapor Pressure: 0.000168mmHg at 25°C
• Melting Point: 268-269℃ (decomposition)
• Refractive Index: 1.603
• Boiling Point: 316.9 °C at 760 mmHg
• PKA: 1.76±0.10(Predicted)
• Flash Point: 145.4 °C
• PSA: 63.32000
• Density: 1.392 g/cm³
• LogP: 2.12470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Aqueous Acid (Slightly), Methanol (Very Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chlorophenylglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Amino(3-?chlorophenyl)?acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.

Technology Process of AMINO-(3-CHLORO-PHENYL)-ACETIC ACID

There total 10 articles about AMINO-(3-CHLORO-PHENYL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(3-chlorophenyl)-2-oxoacetic acid (26767-07-7) → 2-(3-chlorophenyl)glycine (7292-71-9,29884-14-8)

Guidance literature:

With (S)-2-amino-(2-chlorophenyl)ethanoic acid; In water; acetonitrile; at 50 ℃; for 36h; Reflux; Inert atmosphere;

DOI:10.1021/acs.joc.0c01302

Reference yield: 15.0%

methyl 2-(3-chlorophenyl)glycinate (532987-11-4) → 2-(3-chlorophenyl)glycine (7292-71-9,29884-14-8)

Guidance literature:

With potassium hydroxide; In water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01302

Reference yield:

5-(m-chlorophenyl)hydantoin (71737-94-5,74438-96-3) → 2-(3-chlorophenyl)glycine (7292-71-9,29884-14-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/jr9620001440

upstream raw materials:

D‐3‐chlorophenylglycine

5-(m-chlorophenyl)hydantoin

alpha-amino-(3-chlorophenyl)acetonitrile

C₁₆H₁₅ClN₂O

Downstream raw materials:

2-(3-chlorophenyl)aziridine

D‐3‐chlorophenylglycine

L‐3‐chlorophenylglycine

Refernces

• 1、 -. "Method for continuously and quickly preparing DL-phenylglycine and analogue thereof". Paragraph 0037-0039. . Retrieved 2019/07/04.
• 2、 -. "UREAS AS FACTOR XA INHIBITORS". Page/Page column 87. . Retrieved 2010/11/08.