N-(4-Methoxyphenyl)itaconimide

Base Information

• Chemical Name: N-(4-Methoxyphenyl)itaconimide
• CAS No.: 73926-98-4
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• NSC Number: 222702
• UNII: MN4HGH9MK6
• DSSTox Substance ID: DTXSID80995081
• Nikkaji Number: J90.572K
• Wikidata: Q82986282

Synonyms:N-(4-Methoxyphenyl)itaconimide;2,5-Pyrrolidinedione, 1-(4-methoxyphenyl)-3-methylene-;N-p-Anisyl-2-methylenesuccinimide;73926-98-4;Succinimide, N-p-anisyl-2-methylene-;Itaconimide, N-(4-methoxyphenyl)-;1-(4-methoxyphenyl)-3-methylidenepyrrolidine-2,5-dione;MN4HGH9MK6;NSC 222702;BRN 0168517;NSC-222702;1-21-00-00338 (Beilstein Handbook Reference);NSC222702;UNII-MN4HGH9MK6;DTXSID80995081;STL582138;AKOS025148512;2, 1-(4-methoxyphenyl)-3-methylene-;LS-147529;N-(4-Methoxyphenyl)-2-methylenesuccinimide

Chemical Property of N-(4-Methoxyphenyl)itaconimide

Chemical Property:

• Vapor Pressure: 1.51E-05mmHg at 25°C
• Boiling Point: 366°Cat760mmHg
• Flash Point: 175.1°C
• Density: 1.26g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 217.07389321
• Heavy Atom Count: 16
• Complexity: 329

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2C(=O)CC(=C)C2=O

Technology Process of N-(4-Methoxyphenyl)itaconimide

There total 5 articles about N-(4-Methoxyphenyl)itaconimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

itaconic acid anhydride (2170-03-8) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)-3-methylenepyrrolidine-2,5-dione (73926-98-4)

Guidance literature:

itaconic acid anhydride; 4-methoxy-aniline; In diethyl ether; dichloromethane; for 5h; Inert atmosphere;

With sodium acetate; acetic anhydride; at 100 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151063

Reference yield:

4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)-3-methylenepyrrolidine-2,5-dione (73926-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform / 2 h / 20 °C

2: acetic anhydride; sodium acetate / 100 °C

With sodium acetate; acetic anhydride; In chloroform;

DOI:10.1021/acs.jmedchem.0c00584

Reference yield:

N-<4-Methoxy-phenyl>-2-methylen-succinamidsaeure (74448-29-6) → 1-(4-methoxyphenyl)-3-methylenepyrrolidine-2,5-dione (73926-98-4)

Guidance literature:

With sodium acetate; acetic anhydride; at 100 ℃;

DOI:10.1021/acs.jmedchem.0c00584

upstream raw materials:

itaconic acid anhydride

4-methoxy-aniline

N-<4-Methoxy-phenyl>-2-methylen-succinamidsaeure

Downstream raw materials:

3-(tert-butylthiomethyl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione

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