N-(4-methoxyphenyl)-2-butenamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)-2-butenamide
• CAS No.: 95152-22-0
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol file: 95152-22-0.mol

Synonyms:trans-Crotonsaeure-p-anisidid;N-(4-methoxyphenyl)crotonamide;N-(4'-methoxyphenyl)-2-butenamide;trans-crotonic acid p-anisidide;N-(4-methoxyphenyl)-2-butenamide;

Chemical Property of N-(4-methoxyphenyl)-2-butenamide

Chemical Property:

• PSA: 38.33000
• LogP: 2.28280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)-2-butenamide

There total 4 articles about N-(4-methoxyphenyl)-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

trans-chrotonyl chloride (625-35-4,3488-22-0,10487-71-5) + 4-methoxy-aniline (104-94-9) → (2E)-N-(4-methoxyphenyl)-2-butenamide (95152-22-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja108949w

Reference yield: 36.0%

trans-chrotonyl chloride (625-35-4,3488-22-0,10487-71-5) + 4-methoxy-aniline (104-94-9) → (E)-4-hydroxy-N-(4-methoxyphenyl)-2-butenamide + (2E)-N-(4-methoxyphenyl)-2-butenamide (95152-22-0)

Guidance literature:

trans-chrotonyl chloride; 4-methoxy-aniline; With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 48h;

With potassium carbonate; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2014.11.022

Reference yield:

trans-chrotonyl chloride (625-35-4,3488-22-0,10487-71-5) + 4-methoxy-aniline (104-94-9) → (2E)-N-(4-methoxyphenyl)-2-butenamide (95152-22-0) + N-(4'-methoxyphenyl)-3-butenamide (845749-54-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2014.11.022

upstream raw materials:

trans-chrotonyl chloride

4-methoxy-aniline

Downstream raw materials:

methyl 3-(benzyl)propanoate

methyl 4-(3-methoxyphenyl)butanoate

methyl 4-(3,4-dimethoxyphenyl)butanoate

methyl 4-(5-methoxy-2-methylphenyl)butanoate