Hmn-214

Base Information

• Chemical Name: Hmn-214
• CAS No.: 173529-46-9
• Molecular Formula: C₂₂H₂₀N₂O₅S
• Molecular Weight: 424.477
• UNII: 94E9UR0RFR
• DSSTox Substance ID: DTXSID701025981
• Nikkaji Number: J1.992.537D
• Wikidata: Q27271675
• ChEMBL ID: CHEMBL3991927
• Mol file: 173529-46-9.mol

Synonyms:(E)-4-(2-(2-(N-acetyl-N-(4-methoxybenzenesulfonyl)amino)stilbazole)) 1-oxide;HMN-214

Chemical Property of Hmn-214

Chemical Property:

• Boiling Point: 663.1±65.0 °C(Predicted)
• PKA: 0.86±0.10(Predicted)
• PSA: 97.52000
• Density: 1.24
• LogP: 5.11670
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: ≥21.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 424.10929292
• Heavy Atom Count: 30
• Complexity: 689

Purity/Quality:

99% ^*data from raw suppliers

HMN214 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C1=CC=CC=C1C=CC2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC
• Isomeric SMILES: CC(=O)N(C1=CC=CC=C1/C=C/C2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC
• Description: HMN-214 is an orally bioavailable prodrug form of HMN-176, an indirect inhibitor of polo-like kinase (PLK) activity that inhibits proliferation of a variety of cancer cells. HMN-214 decreases the expression of multidrug resistance gene 1 (MDR1) in AB-A.1 cells and in tumors isolated from mice bearing multidrug-resistant KB-A1 xenografts. HMN-214 (20 mg/kg per day) reduces tumor volume in PC3, WiDr, and A549 mouse xenograft models. It does not decrease nerve conduction velocity or compound action potential amplitude in rabbit sciatic nerves in vivo when administered at a concentration of 30 mg/kg per day.
• Uses: HMN 214 is a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. It is a prodrug of HMN 176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1 (PLK1).

Technology Process of Hmn-214

There total 1 articles about Hmn-214 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ HMN-214 (173529-46-9)

Guidance literature:

Refernces