Maytansinol butyrate

Base Information

Chemical Name:Maytansinol butyrate
CAS No.:66547-09-9
Molecular Formula:C32H43ClN2O9
Molecular Weight:635.154
Hs Code.:
European Community (EC) Number:636-289-0
Wikidata:Q76387771

Synonyms:ansamitocin P 3;ansamitocin P 3';ansamitocin P 4;ansamitocins;ansamitomicin p-3

Suppliers and Price of Maytansinol butyrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AnsamitocinP-3’(≥90%)
5mg
$ 105.00

TRC
AnsamitocinP-3’(≥90%)
25mg
$ 195.00

Sigma-Aldrich
Ansamitocin P-3 from Actinosynnema pretiosum ≥90% (HPLC)
1 mg
$ 409.00

DC Chemicals
AnsamitocinP-3 >98%
100 mg
$ 300.00

DC Chemicals
AnsamitocinP-3 >98%
250 mg
$ 600.00

DC Chemicals
AnsamitocinP-3 >98%
1 g
$ 1200.00

Crysdot
Maytansinolbutyrate 98+%
50mg
$ 440.00

Crysdot
Maytansinolbutyrate 98+%
10mg
$ 140.00

Crysdot
Maytansinolbutyrate 98+%
25mg
$ 270.00

ChemScene
AnsamitocinP3'
25mg
$ 300.00

Total 84 raw suppliers

Chemical Property of Maytansinol butyrate

Chemical Property:

Vapor Pressure:8.97E-30mmHg at 25°C
Melting Point:182-185℃
Boiling Point:837.6°Cat760mmHg
PKA:9.83±0.70(Predicted)
Flash Point:460.4°C
PSA：136.16000
Density:1.3g/cm³
LogP:4.71740
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:634.2657086
Heavy Atom Count:44
Complexity:1130

Purity/Quality:

99% ^*data from raw suppliers

AnsamitocinP-3’(≥90%) ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(=O)OC1CC(=O)N(C2=C(C(=CC(=C2)CC(=CC=CC(C3(CC(C(C4C1(O4)C)C)OC(=O)N3)O)OC)C)OC)Cl)C
Isomeric SMILES:CCCC(=O)O[C@H]1CC(=O)N(C2=C(C(=CC(=C2)C/C(=C/C=C/[C@H]([C@]3(C[C@@H]([C@H]([C@H]4[C@]1(O4)C)C)OC(=O)N3)O)OC)/C)OC)Cl)C
Description Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (Kd = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.
Uses Ansamitocin P-3’ is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic.

Technology Process of Maytansinol butyrate

There total 1 articles about Maytansinol butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.2%