N-[3-(dimethylaminodiazenyl)phenyl]-2-piperidin-1-ylacetamide

Base Information

• Chemical Name: N-[3-(dimethylaminodiazenyl)phenyl]-2-piperidin-1-ylacetamide
• CAS No.: 174752-81-9
• Molecular Formula: C15H23N5O
• Molecular Weight: 289.376
• Mol file: 174752-81-9.mol

Synonyms:174752-81-9;N-(3-(3,3-Dimethyltriazeno)phenyl)-2-n-piperidinacetamide;N-[3-(dimethylaminodiazenyl)phenyl]-2-piperidin-1-ylacetamide;N-(3-(3,3-Dimethyl-1-triazenyl)phenyl)-1-piperidineacetamide;1-Piperidineacetamide, N-(3-(3,3-dimethyl-1-triazenyl)phenyl)-;N-{3-[(1E)-3,3-Dimethyl-1-triazen-1-yl]phenyl}-2-(1-piperidinyl)acetamide;N-(3-dimethylaminodiazenylphenyl)-2-(1-piperidyl)acetamide;C15H23N5O;FIKDPYLEYLORDN-UHFFFAOYSA-N;C15-H23-N5-O;LS-113956

Chemical Property of N-[3-(dimethylaminodiazenyl)phenyl]-2-piperidin-1-ylacetamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 63.79000
• Density: 1.16g/cm³
• LogP: 3.25870
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 289.19026037
• Heavy Atom Count: 21
• Complexity: 352

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)N=NC1=CC=CC(=C1)NC(=O)CN2CCCCC2

Technology Process of N-[3-(dimethylaminodiazenyl)phenyl]-2-piperidin-1-ylacetamide

There total 3 articles about N-[3-(dimethylaminodiazenyl)phenyl]-2-piperidin-1-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

piperidine (110-89-4) + N-[3-(3,3-dimethyltriazeno)phenyl]chloroacetamide (174752-85-3) → N-[3-(3,3-dimethyltriazeno)phenyl]-2-N-piperidineacetamide (174752-81-9)

Guidance literature:

In benzene; at 80 ℃; for 3h;

DOI:10.1007/BF02218920

Reference yield:

2-chloro-5-amino-acetanilide → N-[3-(3,3-dimethyltriazeno)phenyl]-2-N-piperidineacetamide (174752-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₂ / aq. HCl / H₂O / 0.5 h / -2 - 0 °C

2: 56 percent / KOH; sodium acetate / H₂O / 3 h / -5 - -2 °C

3: 70 percent / benzene / 3 h / 80 °C

With sodium nitrite; hydrogenchloride; potassium hydroxide; sodium acetate; In water; benzene; 1: Diazotization / 2: azocombination / 3: Substitution;

DOI:10.1007/BF02218920

Reference yield:

3-(2-chloro-acetylamino)-benzenediazonium; chloride → N-[3-(3,3-dimethyltriazeno)phenyl]-2-N-piperidineacetamide (174752-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / KOH; sodium acetate / H₂O / 3 h / -5 - -2 °C

2: 70 percent / benzene / 3 h / 80 °C

potassium hydroxide; sodium acetate; In water; benzene; 1: azocombination / 2: Substitution;

DOI:10.1007/BF02218920

upstream raw materials:

piperidine

N-[3-(3,3-dimethyltriazeno)phenyl]chloroacetamide

Refernces