Base Information
- Chemical Name:2-Thiophenecarboxylic acid, 4-(acetylamino)-
- CAS No.:95576-96-8
- Molecular Formula:C7H7NO3S
- Molecular Weight:
- Hs Code.:
Synonyms:
Synonyms:
The research explores a method for producing acetylamino derivatives of thiophene and furan carboxylic acids or their esters through reductive acetylation using reduced iron in a mixture of acetic acid and acetic anhydride. The purpose is to develop an efficient method for synthesizing these compounds, which are valuable intermediates in drug synthesis. The study concludes that this method yields good results, particularly for 5-alkyl-4-nitro-2-thiophenecarboxylic acids and their esters, achieving higher yields compared to previous methods using skeletal nickel. For instance, a yield of about 80% was achieved for 4-acetylamino-2-thiophenecarboxylic acid from a mixture of nitroacids. The research also demonstrates the stability of certain functional groups under these conditions, such as the retention of chlorine in 4-nitro-5-chloro-2-thiophenecarboxylic acid and partial debromination in 4-nitro-5-bromo-2-thiophenecarboxylic acid. The study provides detailed experimental procedures and characterizes the synthesized compounds through yields, melting points, and elemental analysis.
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