REDUCTIVE ACETYLATION OF NITROCARBOXYLIC ACIDS OF THE THIOPHENE AND FURAN SERIES OR THEIR ESTERS

Article abstract of DOI:10.1007/BF00842830

The corresponding 4-acetylamino-2-thiophenecarboxylic acids or their esters were produced by the action of reduced iron on solutions of 4-nitro-2-thiophenecarboxylic acid, its derivatives, or their esters in a mixture of acetic acid and acetic anhydride.Esters of 5-acetylamino-2-thiophenecarboxylic or 5-acetylamino-2-furancarboxylic acids are formed from esters of 5-nitro-2-thiophenecarboxylic or 5-nitro-2-furancarboxylic acids.Free 5-nitro-2-thiophenecarboxylic and 5-nitro-2-furancarboxylic acids are entirely decomposed under the conditions of reductive acetylation by iron.The ester of 5-acetylamino-3-thiphenecarboxylic acid was obtained from methyl ester of 5-nitro-3-thiophenecarboxylic acid.