2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

Base Information

Chemical Name:2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide
CAS No.:72412-48-7
Molecular Formula:C₁₈H₂₃N₅O₂
Molecular Weight:341.413
Hs Code.:
DSSTox Substance ID:DTXSID50993216
Nikkaji Number:J70.316H
Mol file:72412-48-7.mol

Synonyms:BRN 5609821;72412-48-7;2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-;2-Amino-N-[(1-benzyl-2-pyrrolidinyl)methyl]-4-methoxy-5-pyrimidinecarboxamide;DTXSID50993216;LS-134719;N-[(1-Benzylpyrrolidin-2-yl)methyl]-2-imino-4-methoxy-1,2-dihydropyrimidine-5-carboximidic acid

Suppliers and Price of 2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：97.59000
Density:1.234g/cm³
LogP:1.90460
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:341.18517499
Heavy Atom Count:25
Complexity:430

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC(=NC=C1C(=O)NCC2CCCN2CC3=CC=CC=C3)N

Technology Process of 2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

There total 5 articles about 2-Amino-N-((1-benzyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 72412-48-7
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / 2 h / Heating

2: 81 percent / phosphorus oxychloride / 2 h / 60 °C

3: 95 percent / sodium / Ambient temperature

4: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In pyridine; methanol; water;

Reference yield:

: 72419-36-4
2-amino-4-methoxy-5-methoxycarbonilpyrimidine

: 72412-48-7
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 344311-74-6
2-Acetylamino-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester

: 72412-48-7
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / phosphorus oxychloride / 2 h / 60 °C

2: 95 percent / sodium / Ambient temperature

3: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

4: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In methanol; water;