Glycine, N-[N-[[[4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methoxy-3-oxo propyl]phenyl]amino]thioxomethyl]leucyl]-, (S)-

Base Information

Chemical Name:Glycine, N-[N-[[[4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methoxy-3-oxo propyl]phenyl]amino]thioxomethyl]leucyl]-, (S)-
CAS No.:95753-58-5
Molecular Formula:C₃₄H₃₈N₄O₇S
Molecular Weight:646.764
Hs Code.:

Synonyms:

Suppliers and Price of Glycine, N-[N-[[[4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methoxy-3-oxo propyl]phenyl]amino]thioxomethyl]leucyl]-, (S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of Glycine, N-[N-[[[4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methoxy-3-oxo propyl]phenyl]amino]thioxomethyl]leucyl]-, (S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

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Technology Process of Glycine, N-[N-[[[4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methoxy-3-oxo propyl]phenyl]amino]thioxomethyl]leucyl]-, (S)-

There total 8 articles about Glycine, N-[N-[[[4-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methoxy-3-oxo propyl]phenyl]amino]thioxomethyl]leucyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 615-82-7
DL-Leucyl-glycin

: 88576-96-9
Fmoc-L-p-isothiocyanophenylalanine methyl ester

: 95753-58-5,95753-60-9
N-Fmoc-L-Phe-(p-thiocarbamoyl-DL-Leu-Gly)OMe

Guidance literature:: With triethylamine; In 1,4-dioxane; pyridine; water; 15 min, then 40 deg C, 2 h, dark;
DOI:10.1039/P29840001723

Reference yield:

: 95753-55-2,177966-63-1
N-α-FMOC-4-nitro-L-phenylalanine

: 95753-58-5,95753-60-9
N-Fmoc-L-Phe-(p-thiocarbamoyl-DL-Leu-Gly)OMe

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / 10percent Pd-C / dioxane / 1 h / Ambient temperature

2: SOCl₂

3: 79 percent / 1 M NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

4: 69 percent / 1.) Et₃N / pyridine; dioxane; H₂O / 15 min, then 40 deg C, 2 h, dark

With thionyl chloride; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; pyridine; chloroform; water;
DOI:10.1039/P29840001723

Reference yield:

: 95753-55-2,177966-63-1
N-α-FMOC-4-nitro-L-phenylalanine

: 95753-58-5,95753-60-9
N-Fmoc-L-Phe-(p-thiocarbamoyl-L-Leu-Gly)OMe

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / 10percent Pd-C / dioxane / 1 h / Ambient temperature

2: SOCl₂

3: 79 percent / 1 M NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

4: 1.) Et₃N / pyridine; dioxane; H₂O / 15 min, then 40 deg C, 2 h, dark

With thionyl chloride; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; pyridine; chloroform; water;
DOI:10.1039/P29840001723