Phenylalanine, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-

Base Information

• Chemical Name: Phenylalanine, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-
• CAS No.: 95758-94-4
• Molecular Formula: C11H10F3N3O2
• Molecular Weight: 273.215
• Mol file: 95758-94-4.mol

Synonyms:

Chemical Property of Phenylalanine, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenylalanine, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-

There total 4 articles about Phenylalanine, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C28H26F3N3O2 (1217503-79-1) → C11H10F3N3O2 (95758-94-4)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c9cc09891g

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → C11H10F3N3O2 (95758-94-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: dmap / dichloromethane / 0.08 h / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: pyridine; hydroxylamine hydrochloride / 3 h / 70 °C / Inert atmosphere

3.1: pyridine / 3 h / Reflux; Inert atmosphere

4.1: ammonia / diethyl ether / 12 h / -78 - 20 °C / Sealed tube; Inert atmosphere

5.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C / Inert atmosphere

6.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 70 °C / Inert atmosphere

7.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.2: 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / 2 h / 20 °C / Inert atmosphere

With pyridine; dmap; N-Bromosuccinimide; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; ammonia; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;

DOI:10.1039/c9cc09891g

Reference yield:

2,2,2-trifluoro-1-(p-tolyl)ethanone (394-59-2) → C11H10F3N3O2 (95758-94-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: pyridine; hydroxylamine hydrochloride / 3 h / 70 °C / Inert atmosphere

2.1: pyridine / 3 h / Reflux; Inert atmosphere

3.1: ammonia / diethyl ether / 12 h / -78 - 20 °C / Sealed tube; Inert atmosphere

4.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 70 °C / Inert atmosphere

6.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / 2 h / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; ammonia; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;

DOI:10.1039/c9cc09891g

upstream raw materials:

C₂₈H₂₆F₃N₃O₂

2,2,2-trifluoro-1-(p-tolyl)ethanone

2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone oxime

toluene

Downstream raw materials:

C₁₁H₁₀F₃N₃O₂