9H-Quino[4,3,2-de][1,10]phenanthrolin-9-one

Base Information

• Chemical Name: 9H-Quino[4,3,2-de][1,10]phenanthrolin-9-one
• CAS No.: 114622-04-7
• Molecular Formula: C18H9 N3 O
• Molecular Weight: 283.2836
• Mol file: 114622-04-7.mol

Synonyms:Ascididemin;Ascididemine; CRL 8274; Leptoclinidinone; NSC 675670

Chemical Property of 9H-Quino[4,3,2-de][1,10]phenanthrolin-9-one

Chemical Property:

• Vapor Pressure: 2.32E-14mmHg at 25°C
• Boiling Point: 600.1°Cat760mmHg
• Flash Point: 303.4°C
• PSA: 55.74000
• Density: 1.469g/cm³
• LogP: 3.38940

Purity/Quality:

≥98% （HPLC） ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-Quino[4,3,2-de][1,10]phenanthrolin-9-one

There total 34 articles about 9H-Quino[4,3,2-de][1,10]phenanthrolin-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5,6-dihydroascididemin (155107-75-8) → ascididemin (114622-04-7)

Guidance literature:

With air; In methanol; for 48h;

DOI:10.1055/s-1994-25446

Reference yield: 93.0%

12-(E)-[2-(N',N'-dimethylamino-N-trifluoroacetylamino)ethenyl]benzo[b]acridine-6,11-dione (460041-66-1) → ascididemin (114622-04-7)

Guidance literature:

With sodium acetate; ammonium chloride; In ethanol; Heating;

DOI:10.1039/a905234h

Reference yield: 84.0%

11-(E)-[2-(N',N'-dimethylamino-N-trifluoroacetylamino)ethenyl]pyrido[2,3-b]acridine-5,12-dione (460041-69-4) → ascididemin (114622-04-7)

Guidance literature:

With sodium acetate; ammonium chloride; In ethanol; for 0.333333h; Heating;

DOI:10.1039/b202555h

upstream raw materials:

2-bromoleptoclinidinone

N-(2-iodophenyl)-1,10-phenanthroline-5,6-quinone monoimine

5,6-dihydroascididemin

formaldehyd

Refernces

• 1、 Lindsay, Brent S.,Pearce, A. Norrie,Copp, Brent R.. "Efficient and convenient pyridine ring-e formation of the cytotoxic marine alkaloid ascididemin and related analogues". . p. 2587 - 2592. Retrieved 1997.
• 2、 Wumaier, Maierhaba,Shi, Jing-Jing,Yao, Tian-Ming,Hu, Xiao-Chun,Gao, Ru-Ru,Shi, Shuo. "G-quadruplex and duplex DNA binding studies of novel Ruthenium(II) complexes containing ascididemin ligands". . . Retrieved 2019/04/17.
• 3、 Petersen, Ida Nymann,Crestey, Francois,Kristensen, Jesper Langgaard. "Total synthesis of ascididemin via anionic cascade ring closure". supporting information. p. 9092 - 9094,3. Retrieved 2020/08/31.