N-(2-propanoylphenyl)acetamide

Base Information

• Chemical Name: N-(2-propanoylphenyl)acetamide
• CAS No.: 52457-99-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Hs Code.: 2924299090
• European Community (EC) Number: 668-649-8
• NSC Number: 163518
• DSSTox Substance ID: DTXSID00303922
• Wikidata: Q82049431
• Mol file: 52457-99-5.mol

Synonyms:N-(2-propanoylphenyl)acetamide;52457-99-5;N-(2-Propionylphenyl)acetamide;NSC163518;o-propionylacetanilide;SCHEMBL6421670;DTXSID00303922;AKOS024324257;NSC-163518

Chemical Property of N-(2-propanoylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 7.2E-06mmHg at 25°C
• Boiling Point: 376.5°Cat760mmHg
• Flash Point: 162.3°C
• PSA: 46.17000
• Density: 1.121g/cm³
• LogP: 2.31070
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 191.094628657
• Heavy Atom Count: 14
• Complexity: 225

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'-PROPIONYLACETANILIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(=O)C1=CC=CC=C1NC(=O)C

Technology Process of N-(2-propanoylphenyl)acetamide

There total 8 articles about N-(2-propanoylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2'-Aminopropiophenon (1196-28-7) + acetyl chloride (75-36-5) → 1-(2-acetylaminophenyl)-1-propanone (52457-99-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 76.0%

2-Oxobutyric acid (600-18-0) + Acetanilid (103-84-4) → 1-(2-acetylaminophenyl)-1-propanone (52457-99-5)

Guidance literature:

With ammonium peroxydisulfate; palladium(II) trifluoroacetate; In diethylene glycol dimethyl ether; at 20 ℃;

DOI:10.1021/ja105245f

Reference yield: 50.0%

propionaldehyde (123-38-6) + Acetanilid (103-84-4) → 1-(2-acetylaminophenyl)-1-propanone (52457-99-5)

Guidance literature:

With tert.-butylhydroperoxide; tris(pentafluorophenyl)borate; palladium diacetate; In decane; dichloromethane; at 30 ℃; for 18h; Inert atmosphere; Glovebox; Sealed tube; Molecular sieve;

DOI:10.1021/acs.organomet.5b01017

upstream raw materials:

2'-Aminopropiophenon

acetic anhydride

1-(2-nitrophenyl)propanone

3-[3-(O-acetamido)-phenyl]-propyl alcohol

Downstream raw materials:

4-chloro-3-methylquinoline

N-(2-(3-hydroxypent-1-yn-3-yl)phenyl)acetamide

(E)-N-(4-ethylquinolin-2(1H)-ylidene)-4-methylbenzenesulfonamide

2'-Aminopropiophenon