3-(TrifluoroMethyl)butyraldehyde

Base Information

• Chemical Name: 3-(TrifluoroMethyl)butyraldehyde
• CAS No.: 95853-69-3
• Molecular Formula: C5H7F3O
• Molecular Weight: 140.10400
• Hs Code.: 2913000090
• Mol file: 95853-69-3.mol

Synonyms:

Chemical Property of 3-(TrifluoroMethyl)butyraldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 1.77380

Purity/Quality:

3-Trifluoromethylbutyraldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Trifluoromethylbutyraldehyde is a reactant in the synthesis of nonproteinogenic amino acids.

Technology Process of 3-(TrifluoroMethyl)butyraldehyde

There total 5 articles about 3-(TrifluoroMethyl)butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(+/-)-4,4,4-Trifluor-3-methyl-1-butanol (339-62-8) → (+/-)-4,4,4-Trifluor-3-methyl-1-butanal (95853-69-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 1.5h; Ambient temperature;

Reference yield:

4,4,4-trifluoro-N-methoxy-N, 3-dimethylbutanamide → (+/-)-4,4,4-Trifluor-3-methyl-1-butanal (95853-69-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

(E)-3-trifluoromethyl-2-butenoic acid ethyl ester (691-77-0) → (+/-)-4,4,4-Trifluor-3-methyl-1-butanal (95853-69-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / Pd/C (10 percent Pd) / 6 h / Ambient temperature

2: 86 percent / LiAlH₄ / diethyl ether / 2 h / Heating

3: 80 percent / PCC / CH₂Cl₂ / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; pyridinium chlorochromate; 10% palladium on active carbon; In diethyl ether; dichloromethane;

upstream raw materials:

(+/-)-4,4,4-Trifluor-3-methyl-1-butanol

(E)-3-trifluoromethyl-2-butenoic acid ethyl ester

(+/-)-ethyl 4,4,4-trifluoro-3-methylbutanoate

Downstream raw materials:

(2R,4S)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril

(2R,4R)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril

(2S,4S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril

(2S,4R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril