691-77-0

Upstream product

• 64-17-5 ethanol 
• 69056-67-3 3-methyl-4,4,4-trifluoro-2-butenoic acid 
• 649-67-2 4,4,4-Trifluor-3-hydroxy-3-methyl-butansaeure-⁽¹⁾-ethylester 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 338-03-4 4,4,4-trifluoro-3-hydroxy-3-methyl-butanoic acid 

Downstream Products

• 145653-35-6 (3R*,4R*,5R*)-2-benzyl-3,4-diethoxycarbonyl-5-methyl-5-trifluoromethylisoxazolidine 
• 145653-35-6 (3R*,4S*,5S*)-2-benzyl-3,4-diethoxycarbonyl-5-methyl-5-trifluoromethylisoxazolidine 
• 6975-13-9 (+/-)-ethyl 4,4,4-trifluoro-3-methylbutanoate 
• 348-75-4 (-)-3-trifluoromethylbutanoic acid 
• 114136-63-9 3-(4-chloro-2-fluorophenyl)-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione 
• 400-28-2 (2E)-4,4,4-Trifluoro-3-methylbut-2-enoic acid 
• 6975-13-9 (R)-4,4,4-Trifluoro-3-methyl-butyric acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of new β-trifluoromethyl containing GABA and β-fluoromethyl containing N-benzylpyrrolidinones

A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N-benzylpyrrolidinones 5a-c was synthesized by deoxyfluorination of corresponding 3-functionalized N-benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N-benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.

1-Bromo-3-trifluoromethylbut-2-ene: synthesis and electrophilic reactivity

A three-step synthesis of 1-bromo-3-trifluoromethylbut-2-ene in 54percent overall yield is reported starting from 1,1,1-trifluoroacetone.The electrophilic reactivity of this compound towards various nucleophiles has been studied.Thus, for example, condensation with the sodium salt of diethyl malonate gave ethyl 2-carboethoxy-5-trifluoromethylhex-4-enoate in 66percent yield.

Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones

A series of substituted analogues based on the novel 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-dione ring system have been synthesized and shown to exhibit antiinflammatory activity in the adjuvant-induced arthritis rat model (AAR). The activi

Efforts in Synthesizing α,β-Unsaturated Trifluoromethyl-substituted Aldehydes

Hexafluoroacetone reacts with ethynylmagnesium bromide to yield (CF3)2C(OH)-CCH (1).Bromine can be added to the triple bond affording the cis/trans-isomer 2.With PCl5 1 yields the allene (CF3)2C=C=CClH (3).The addition of a metalated Schiff base to hexafluoroacetone leads to 4a which on hydrolysis yields (CF3)2C(OH)-CH2-CHO (4b).The reaction of (EtO)2P(O)CH2-R (R = CHO, CO2Et) with hexafluoroacetone gives α,β-unsaturated aldehydes or esters 6. 1,1,1-Trifluoroacetone provides analogous reactions.

Synthesis and Thermolysis of Highly Halogenated Δ1-Pyrazolines

The pyrolysis of highly halogenated Δ1-pyrazolines gives, in addition to cyclopropanes, rearranged olefins.