7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid
CAS No.:178233-18-6
Molecular Formula:C₁₈H₁₉F₂N₃O₃
Molecular Weight:363.364
Hs Code.:
DSSTox Substance ID:DTXSID90939057
Nikkaji Number:J733.830I
Mol file:178233-18-6.mol

Synonyms:178233-18-6;(S)-7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;7-[(3S)-3-aminopyrrolidin-1-yl]-1-cyclopropyl-6,8-difluoro-5-methyl-4-oxoquinoline-3-carboxylic acid;7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid;DTXSID90939057;7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Suppliers and Price of 7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid

Chemical Property:

Vapor Pressure:1.94E-15mmHg at 25°C
Boiling Point:604°Cat760mmHg
Flash Point:319.1°C
PSA：0.00000
Density:1.507g/cm³
LogP:0.00000
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:363.13944780
Heavy Atom Count:26
Complexity:654

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C2C(=C(C(=C1F)N3CCC(C3)N)F)N(C=C(C2=O)C(=O)O)C4CC4
Isomeric SMILES:CC1=C2C(=C(C(=C1F)N3CC[C@@H](C3)N)F)N(C=C(C2=O)C(=O)O)C4CC4

Technology Process of 7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid

There total 2 articles about 7-((S)-3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99724-19-3,140629-77-2
3-(tert-butoxycarbonylamino)pyrrolidine

: 119915-54-7
1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid

: 119914-64-6,178233-18-6
7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With hydrogenchloride; acetic acid; triethylamine; Yield given. Multistep reaction; 1.) CH₃CN, reflux, 6 h;
DOI:10.1021/jm00107a040