79286-79-6

Basic information

• Product Name: 3-Aminopyrrolidine
• Synonyms: PYRROLIDIN-3-YLAMINE;3-AMINOPYRROLIDINE;3-PYRROLIDINAMINE;3-AMINOPYRROLIDINE 98+%;pyrrolidin-3-amine;3-Pyrrolidinylamine;Pyrrolidine-3-amine;4-Amino Pyrrolidine
• CAS NO: 79286-79-6
• Molecular Formula: C₄H₁₀N₂
• Molecular Weight: 86.14
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline;3-Aminopyrrolidines;3-Aminopyrrolidines (Racemic)
• Mol File: 79286-79-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 132.2 ºC at 760 mmHg
• Flash Point: 33.7 ºC
• Appearance: /
• Density: 0.98
• Refractive Index: 1.4880-1.4910
• Storage Temp.: 2-8°C
• PKA: 9.94±0.20(Predicted)
• CAS DataBase Reference: 3-Aminopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminopyrrolidine(79286-79-6)
• EPA Substance Registry System: 3-Aminopyrrolidine(79286-79-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: 2735
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 79286-79-6(Hazardous Substances Data)

Usage

General Description

3-Aminopyrrolidine, also known as 3-AP, is a chemical compound with the molecular formula C4H10N2. It is a heterocyclic amine that contains a pyrrolidine ring, which is a five-membered nitrogen-containing ring. 3-Aminopyrrolidine is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds. It has also been studied for its potential as a therapeutic agent in the treatment of cancer, as it has been found to inhibit the growth of tumor cells in preclinical studies. Additionally, 3-Aminopyrrolidine has been investigated for its use as a chiral auxiliary in asymmetric synthesis to produce enantiomerically pure compounds. Overall, 3-Aminopyrrolidine is a versatile chemical with potential applications in various fields of science and industry.

Upstream product

• 18471-40-4 1-Benzyl-3-aminopyrrolidine 
• 114715-38-7 (3S)-1-benzyl-3-pyrrolidinamine 
• 122536-76-9 3(S)-(tert-butoxycarbonylamino)pyrrolidine 
• 56440-28-9 (S)-3-amino-2-pyrrolidinone hydrochloride 

Downstream Products

• 17741-13-8 3-(phenylamino)pyrrolidine 
• 18471-41-5 3-amino-1-phenylpyrrolidine 
• 99724-19-3 3-(tert-butoxycarbonylamino)pyrrolidine 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 820985-21-5 (3S)-N {(E)-[2-(trifluoromethyl)phenyl]methylidene}-pyrrolidin-3-amine 
• 820985-23-7 (3S)-N {[2-(trifluoromethyl)phenyl]methyl}-pyrrolidin-3-amine 
• 186550-13-0 3-amino-1-(t-butoxycarbonyl)pyrrolidine 
• 79286-77-4 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 79286-79-6 (3S)-3-aminopyrrolidine 
• 116183-82-5 (R)-pyrrolidin-3-amine 
• 866003-45-4 (S)-tert-butyl 4-(3-aminopyrrolidin-1-yl)benzoate 
• 1057666-80-4 (S)-tert-butyl 2-(6-(3-aminopyrrolidin-1-yl)nicotinamido)phenylcarbamate 

Relevant articles and documents

Synthesis of 6-oxopyrimidin-1(6H)-yl benzamide derivatives and evaluation of their antibacterial and cytotoxic activity

A series of novel 2-alkylamino and 2, 4-dialkyl amino 6-oxopyrimidin-1(6H)-yl) benzamide derivatives were prepared in good yields from a base-catalyzed ring opening of oxadiazolo[3,2-a]pyrimidin-5-one and evaluated for their antibacterial and cytotoxicity. Most of the compounds exhibited antibacterial activity. In particular, compounds 5b and 5k exhibited considerable antibiotic activity against Klebsiella pneumonia and Bacillus cereus. In addition, compounds 5g and 5i also inhibited the growth of two human tumor cell lines (A549 and H460) at micromolar concentrations.

PROCESS FOR PRODUCING NITROGENOUS HETEROCYCLIC COMPOUND

A nitrogenous heterocyclic compound such as 3-aminopyrrolidine derivative is produced by hydrogenolysis of an N-substituted nitrogenous heterocyclic compound with normal pressure hydrogen in a water-based solvent in presence of a catalyst. In the case an optically active 1-substituted-3-aminopyrrrolidine derivative is used as a raw material, an optically active 3-aminopyrrolidine derivative can be obtained as a product practically without racemination.

Methods for making optically active 3-aminopyrrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative

A method for making an optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) includes cyclizing an optically active asparagine ester derivative represented by the formula (1) or (2) or an acid salt thereof. The optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) may be reduced to form an optically active 3-aminopyrrolidine derivative represented by the formula (9). When, in the formula (9), R1 is an unsubstituted or substituted benzyl group, the compound may be hydrogenated to obtain the corresponding 1-unsubstituted compound in which R1 is hydrogen.