DL-Amethopterin

Base Information

Chemical Name:DL-Amethopterin
CAS No.:51865-79-3
Deprecated CAS:184883-35-0
Molecular Formula:C₂₀H₂₂N₈O₅
Molecular Weight:454.445
Hs Code.:29335995
European Community (EC) Number:262-213-7
NSC Number:757113,117356
UNII:99ITO15X8S
DSSTox Substance ID:DTXSID40859034
Wikidata:Q27165469
ChEMBL ID:CHEMBL426
Mol file:51865-79-3.mol

Synonyms:60388-53-6;DL-Amethopterin;(+/-)Amethopterin;DL-Methotrexate;(+)-Amethopterin;METHOTREXATE(+/-);TCMDC-123832;6-Mtx (DL);(+-)-Methotrexate;Amethopterin (R,S);EINECS 262-213-7;Methotrexate, (+/-)-;Methotrexate;2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid;MLS002701970;99ITO15X8S;D(-)-AMETHOPTERIN;2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;NSC-117356;NSC-757113;C20H22N8O5;N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid;N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid;NSC 117356;DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-;Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, DL-;C19H23N9O4;Emtexate;2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid;Methotrexate (hydrate);SR-05000001673;NSC117356;4-Amino-N10-methylpteroylglutamic acid;GLUTAMIC ACID, N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)METHYLAMINO)BENZOYL)-;Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-;N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-DL-glutamic acid;Prestwick_753;Folex (Salt/Mix);DL-MTX;Prestwick0_000373;Prestwick1_000373;Prestwick2_000373;Prestwick3_000135;Prestwick3_000373;CHEMBL426;Methotrexate, (DL)-Isomer;SCHEMBL3712;UNII-99ITO15X8S;BSPBio_000210;BSPBio_000525;BSPBio_001993;Amethopterin;ChEMBL_59579;(+/-)-METHOTREXATE;SPECTRUM1500398;SPBio_002446;Amethopterin (hydrate);CL14377 (hydrate);WR19039 (hydrate);BPBio1_000232;BPBio1_000579;Methotrexate pound>>Amethopterin;SCHEMBL11986730;SCHEMBL20369096;CHEBI:93775;DTXSID40859034;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-;HMS1569K07;HMS1920L21;HMS2091D16;HMS2096K07;HMS3267F07;HMS3371G08;HMS3403O03;HMS3654M22;HMS3713K07;HMS3869E13;Pharmakon1600-01500398;BCP02078;BCP29918;BDBM50004545;NSC757113;AKOS000281496;AKOS024282621;AB02593;CCG-212689;NCGC00015079-03;NCGC00015079-04;NCGC00015079-07;NCGC00095284-01;NCGC00095284-02;AC-11680;LS-71811;NCI60_041622;SMR001565548;SBI-0053664.P003;Kyselina 4-amino-N10-methylpteroylglutamova;FT-0601523;FT-0630651;M1664;EN300-296152;SR-05000001673-1;SR-05000001673-2;BRD-A55424491-001-07-4;BRD-A55424491-001-08-2;Q27165469;(MTX)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid;2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioicacid;2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(MTX);N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)METHYLAMINO)BENZOYL)GLUTAMIC ACID;N-(4-[[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino]benzoyl)glutamic acid, (L)-;N-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid;N-(p-((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid, (L)-;(methotrexate)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid;(Methotrexate, MTX)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid;2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid;2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (Methotrexate);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (MTX);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid bis-adamantan-1-ylamide;2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Amethopterin);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate (MTX));2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate );2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(methotrexate(MTX));2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate, MXT);4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(methotrexate, MTX);Methotrexate2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid

Suppliers and Price of DL-Amethopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Methotrexate
1mg
$ 180.00

TRC
(R)-Methotrexate
25mg
$ 2775.00

Sigma-Aldrich
(?)-Amethopterin United States Pharmacopeia (USP) Reference Standard
5mg
$ 1260.00

Medical Isotopes, Inc.
(R)-Methotrexate
1 mg
$ 650.00

American Custom Chemicals Corporation
D-(-)-AMETHOPTERIN 95.00%
25MG
$ 650.33

Total 18 raw suppliers

Chemical Property of DL-Amethopterin

Chemical Property:

Melting Point:195 °C
Refractive Index:1.6910 (estimate)
Boiling Point:°Cat760mmHg
PKA:3.47±0.10(Predicted)
Flash Point:°C
PSA：210.54000
Density:1.536g/cm³
LogP:1.82170
Storage Temp.:-20°C
XLogP3:-1.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:9
Exact Mass:454.17131583
Heavy Atom Count:33
Complexity:704

Purity/Quality:

97% ^*data from raw suppliers

(R)-Methotrexate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 61-46-25-36/37/38-60-23/24/25
Safety Statements: 53-45-28A-36/37/39-26-22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Recent ClinicalTrials:Study of the Efficacy and Safety of BCD-089 in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis

Technology Process of DL-Amethopterin

There total 1 articles about DL-Amethopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: