DL-Amethopterin

Base Information

Chemical Name:DL-Amethopterin
CAS No.:60388-53-6
Deprecated CAS:184883-35-0
Molecular Formula:C20H22N8O5
Molecular Weight:454.445
Hs Code.:
European Community (EC) Number:262-213-7
NSC Number:757113,117356
UNII:99ITO15X8S
DSSTox Substance ID:DTXSID40859034
Wikidata:Q27165469
ChEMBL ID:CHEMBL426

Synonyms:60388-53-6;DL-Amethopterin;(+/-)Amethopterin;DL-Methotrexate;(+)-Amethopterin;METHOTREXATE(+/-);TCMDC-123832;6-Mtx (DL);(+-)-Methotrexate;Amethopterin (R,S);EINECS 262-213-7;Methotrexate, (+/-)-;Methotrexate;2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid;MLS002701970;99ITO15X8S;D(-)-AMETHOPTERIN;2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;NSC-117356;NSC-757113;C20H22N8O5;N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid;N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid;NSC 117356;DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-;Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, DL-;C19H23N9O4;Emtexate;2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid;Methotrexate (hydrate);SR-05000001673;NSC117356;4-Amino-N10-methylpteroylglutamic acid;GLUTAMIC ACID, N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)METHYLAMINO)BENZOYL)-;Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-;N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-DL-glutamic acid;Prestwick_753;Folex (Salt/Mix);DL-MTX;Prestwick0_000373;Prestwick1_000373;Prestwick2_000373;Prestwick3_000135;Prestwick3_000373;CHEMBL426;Methotrexate, (DL)-Isomer;SCHEMBL3712;UNII-99ITO15X8S;BSPBio_000210;BSPBio_000525;BSPBio_001993;Amethopterin;ChEMBL_59579;(+/-)-METHOTREXATE;SPECTRUM1500398;SPBio_002446;Amethopterin (hydrate);CL14377 (hydrate);WR19039 (hydrate);BPBio1_000232;BPBio1_000579;Methotrexate pound>>Amethopterin;SCHEMBL11986730;SCHEMBL20369096;CHEBI:93775;DTXSID40859034;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-;HMS1569K07;HMS1920L21;HMS2091D16;HMS2096K07;HMS3267F07;HMS3371G08;HMS3403O03;HMS3654M22;HMS3713K07;HMS3869E13;Pharmakon1600-01500398;BCP02078;BCP29918;BDBM50004545;NSC757113;AKOS000281496;AKOS024282621;AB02593;CCG-212689;NCGC00015079-03;NCGC00015079-04;NCGC00015079-07;NCGC00095284-01;NCGC00095284-02;AC-11680;LS-71811;NCI60_041622;SMR001565548;SBI-0053664.P003;Kyselina 4-amino-N10-methylpteroylglutamova;FT-0601523;FT-0630651;M1664;EN300-296152;SR-05000001673-1;SR-05000001673-2;BRD-A55424491-001-07-4;BRD-A55424491-001-08-2;Q27165469;(MTX)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid;2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioicacid;2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(MTX);N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)METHYLAMINO)BENZOYL)GLUTAMIC ACID;N-(4-[[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino]benzoyl)glutamic acid, (L)-;N-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid;N-(p-((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid, (L)-;(methotrexate)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid;(Methotrexate, MTX)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid;2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid;2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (Methotrexate);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (MTX);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid bis-adamantan-1-ylamide;2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Amethopterin);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate (MTX));2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate );2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(methotrexate(MTX));2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate);2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid(Methotrexate, MXT);4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(methotrexate, MTX);Methotrexate2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid

Suppliers and Price of DL-Amethopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DL-MethotrexateDipotassiumSaltDihydrate
250mg
$ 1190.00

Medical Isotopes, Inc.
DL-MethotrexateDipotassiumSaltDihydrate
25 mg
$ 650.00

AvaChem
Racemethotrexate
100mg
$ 129.00

AvaChem
Racemethotrexate
25mg
$ 59.00

AvaChem
Racemethotrexate
10mg
$ 39.00

American Custom Chemicals Corporation
DL-AMETHOPTERIN 95.00%
100MG
$ 636.16

Total 18 raw suppliers

Chemical Property of DL-Amethopterin

Chemical Property:

Appearance/Colour:yellow to orange crystalline powder
Melting Point:195 °C (dec.)(lit.)
PKA:3.47±0.10(Predicted)
PSA：210.54000
Density:1.536 g/cm³
LogP:1.82170
Storage Temp.:?20°C
Solubility.:H2O: Add a minimal amount of 0.1燦 NaOH to solubilize, then dilute in neutral buffer or saline. Diluted stock is stable for 1爓eek refrigerated and for 1爉onth frozen at?#8722;20?#x00b0;C.insoluble
XLogP3:-1.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:9
Exact Mass:454.17131583
Heavy Atom Count:33
Complexity:704

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-MethotrexateDipotassiumSaltDihydrate ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes: T:Toxic;
Statements: R46:May cause heritable genetic damages.; R61:May cause harm to the unborn child.;
Safety Statements: S45:In case of accident of if you feel unwell, seek medical advice immediately (show the label where possible).; S53:Avoi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Recent ClinicalTrials:Study of the Efficacy and Safety of BCD-089 in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis
Uses Amethopterin is an antineoplastic, antirheumatic, folic acid antagonist Racemic Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic. (+/-)Amethopterin is a folic acid antagonist and anticancer agent.

Technology Process of DL-Amethopterin

There total 2 articles about DL-Amethopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: