(R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate
CAS No.:96163-73-4
Molecular Formula:C9H14ClNO3
Molecular Weight:219.668
Hs Code.:
DSSTox Substance ID:DTXSID601269356
Mol file:96163-73-4.mol

Synonyms:(R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate;96163-73-4;ETHYL (2R)-1-(2-CHLOROACETYL)PYRROLIDINE-2-CARBOXYLATE;DTXSID601269356;AKOS024463441;D-Proline, 1-(chloroacetyl)-, ethyl ester;A858705;(R)-Ethyl1-(2-chloroacetyl)pyrrolidine-2-carboxylate

Suppliers and Price of (R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-Ethyl1-(2-chloroacetyl)pyrrolidine-2-carboxylate 95+%
1g
$ 527.00

Chemenu
(R)-Ethyl1-(2-chloroacetyl)pyrrolidine-2-carboxylate 95%
1g
$ 497.00

Alichem
(R)-Ethyl1-(2-chloroacetyl)pyrrolidine-2-carboxylate
1g
$ 430.00

Total 8 raw suppliers

Chemical Property of (R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate

Chemical Property:

Boiling Point:135-136 °C (1 mmHg)
PSA：46.61000
Density:1.244±0.06 g/cm3(20 °C , 760mmHg)
LogP:0.71720
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:219.0662210
Heavy Atom Count:14
Complexity:232

Purity/Quality:

97% ^*data from raw suppliers

(R)-Ethyl1-(2-chloroacetyl)pyrrolidine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CCCN1C(=O)CCl
Isomeric SMILES:CCOC(=O)[C@H]1CCCN1C(=O)CCl

Technology Process of (R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate

There total 2 articles about (R)-Ethyl 1-(2-chloroacetyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 96163-72-3
ethyl proline hydrochloride

: 79-04-9
chloroacetyl chloride

: 96163-73-4
N-Chloroacetyl-D-proline ethyl ester

Guidance literature:: With triethylamine; In benzene; Ambient temperature;
DOI:10.1007/BF00768332

Reference yield:

: 344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7
D-Prolin

: 96163-73-4
N-Chloroacetyl-D-proline ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89.4 percent / SOCl₂

2: 72.5 percent / Et₃N / benzene / Ambient temperature

With thionyl chloride; triethylamine; In benzene;
DOI:10.1007/BF00768332