4-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

Base Information

• Chemical Name: 4-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
• CAS No.: 96256-53-0
• Molecular Formula: C10H7F3N2
• Molecular Weight: 212.174
• Mol file: 96256-53-0.mol

Synonyms:3-trifluoromethyl-4-phenylpyrazole;

Chemical Property of 4-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

Chemical Property:

• PSA: 28.68000
• LogP: 3.09550

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Phenyl-3-(trifluoromethyl)-1H-pyrazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

There total 3 articles about 4-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2,2-trifluorodiazoethane (371-67-5) + (2-nitroethenyl)benzene (102-96-5) → 4-phenyl-3-(trifluoromethyl)-1H-pyrazole (96256-53-0)

Guidance literature:

With sodium phosphate; silver(l) oxide; In tetrahydrofuran; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Schlenk technique;

DOI:10.1002/anie.201700955

Reference yield:

C14H15F3N2O → 4-phenyl-3-(trifluoromethyl)-1H-pyrazole (96256-53-0)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 1h;

DOI:10.1016/j.tet.2012.10.034

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3,3,3-trifluoro-1-phenylpropyne (772-62-3) → 4-phenyl-3-(trifluoromethyl)-1H-pyrazole (96256-53-0) + 3-Phenyl-4-trifluoromethyl-1H-pyrazole (96256-52-9)

Guidance literature:

In diethyl ether;

upstream raw materials:

diazomethane

3,3,3-trifluoro-1-phenylpropyne

2,2,2-trifluorodiazoethane

(2-nitroethenyl)benzene

Downstream raw materials:

C₁₀H₆F₃IN₂

4-phenyl-1H-pyrazole-3-carbonitrile

4-phenyl-1H-pyrazole-3-carboxylic acid

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