4-Phenyl-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 4-Phenyl-1H-pyrazole-3-carboxylic acid
• CAS No.: 7510-56-7
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.186
• Mol file: 7510-56-7.mol

Synonyms:4-Phenyl-pyrazol-3(5)-carbonsaeure;1-phenyl-4-(2,3,5,6-tetramethyl-phenyl)-phthalazine;4-Phenyl-1-(1,3,5,6-tetramethylphenyl)phthalazin;4-Phenyl-pyrazol-carbonsaeure-(3);4-Phenyl-1(2)H-pyrazol-3-carbonsaeure;4-phenyl-1H-pyrazole-3-carboxylic acid;4-Phenyl-pyrazol-3-carbonsaeure;Phthalazine,1-phenyl-4-(2,3,5,6-tetramethylphenyl);4-phenyl-1(2)H-pyrazole-3-carboxylic acid;

Chemical Property of 4-Phenyl-1H-pyrazole-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 3.2E-08mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 431.8 °C at 760 mmHg
• Flash Point: 214.9 °C
• PSA: 65.98000
• Density: 1.355 g/cm³
• LogP: 1.77490
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Phenyl-1H-pyrazole-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Phenyl-1H-pyrazole-3-carboxylic acid

There total 18 articles about 4-Phenyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-phenyl-1H-pyrazole-3-carboxylic acid methyl ester (5932-28-5,856061-35-3) → 4-phenyl-1H-pyrazole-3-carboxylic acid (7510-56-7,856061-36-4)

Guidance literature:

With hydrogenchloride; In water; for 3h; Reflux;

DOI:10.1002/jhet.1654

Reference yield: 40.0%

4-phenyl-3-(trifluoromethyl)-1H-pyrazole (96256-53-0) → 4-phenyl-1H-pyrazole-3-carboxylic acid (7510-56-7,856061-36-4)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 120 ℃; for 1h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.tet.2012.10.034

Reference yield:

3-cyano-4-phenyl-5-trimethylsilylpyrazole (89864-91-5) → 4-phenyl-1H-pyrazole-3-carboxylic acid amide (844443-61-4) + 4-phenyl-1H-pyrazole-3-carboxylic acid (7510-56-7,856061-36-4)

Guidance literature:

3-cyano-4-phenyl-5-trimethylsilylpyrazole; With potassium hydroxide; water; In ethanol; at 150 - 170 ℃; for 0.833333h; microwave irradiation;

With hydrogenchloride; water; In ethanol; pH=1;

upstream raw materials:

4-phenyl-1H-pyrazole-3-carboxylic acid methyl ester

ethyl 4-phenyl-1H-pyrazole-3-carboxylate

3-Methyl-4-phenyl-1H-pyrazole

methyl (Z)-2-(acetylamino)-3-phenylpropenoate

Downstream raw materials:

1-methyl-4-phenyl-1H-pyrazole

4-phenyl-1H-pyrazole