1H-Indole-2-propanoic acid, a-(acetylamino)-, ethyl ester

Base Information

• Chemical Name: 1H-Indole-2-propanoic acid, a-(acetylamino)-, ethyl ester
• CAS No.: 96286-14-5
• Molecular Formula: C15H18N2O3
• Molecular Weight: 274.32
• Mol file: 96286-14-5.mol

Synonyms:

Chemical Property of 1H-Indole-2-propanoic acid, a-(acetylamino)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-2-propanoic acid, a-(acetylamino)-, ethyl ester

There total 2 articles about 1H-Indole-2-propanoic acid, a-(acetylamino)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H17N2(1+)*CH3O4S(1-) (95242-11-8) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → ethyl 2-acetamido-3-(2-indolyl)propionate (96286-14-5) + diethyl 2-acetamido-2-<(2-indolyl)methyl>malonate (13373-31-4) + Diethyl carbonate (105-58-8,76619-83-5)

Guidance literature:

With sodium; Yield given. Multistep reaction;

DOI:10.1246/bcsj.58.123

Reference yield:

C12H17N2(1+)*CH3O4S(1-) (95242-11-8) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → ethyl 2-acetamido-3-(2-indolyl)propionate (96286-14-5) + diethyl 2-acetamido-2-<(2-indolyl)methyl>malonate (13373-31-4)

Guidance literature:

With sodium; Yield given. Multistep reaction. Yields of byproduct given; ethanol; 20 deg C; 3 days;;

DOI:10.1246/bcsj.58.123

Reference yield:

ethyl 2-acetamido-3-(2-indolyl)propionate (96286-14-5) → 3-amino-1-methyl-5H-pyrido[4,3-b]indole (62450-07-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / Na₂CO₃ / H₂O / Heating

2: 87 percent / thionyl chloride / Heating

3: 98 percent / sulfur / xylene / Heating; lead tetraacetate as reagent in pyridine;

4: 96 percent / aq.NaOH / ethanol / Heating

5: diphenylphosphoryl azide; triethylamine; acetic acid; NaOH;

With sodium hydroxide; thionyl chloride; diphenylphosphoranyl azide; sodium carbonate; sulfur; acetic acid; triethylamine; In ethanol; water; xylene;

DOI:10.1246/bcsj.58.123

upstream raw materials:

C₁₂H₁₇N₂⁽¹⁺⁾*CH₃O₄S^(1-)

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

3-amino-1-methyl-5H-pyrido[4,3-b]indole

1-methyl-5H-pyrido<4,3-b>indole-3-carboxylic acid