13373-31-4 Usage
General Description
1-Acetamido(1H-indol-2-yl)methyl3-ethyl2-ethylmalonate is a complex chemical compound with a unique structure. It consists of an acetamido group, an indolylmethyl group, and two ethyl groups attached to a malonate molecule. The presence of the acetamido group suggests that it may have pharmaceutical potential, as this group is found in many drugs to improve their solubility and bioavailability. The indolylmethyl group is derived from the indole molecule, which is known for its diverse biological activities, including anti-inflammatory, anti-oxidant, and anti-cancer properties. With this combination of functional groups, 1-Acetamido(1H-indol-2-yl)methyl3-ethyl2-ethylmalonate may hold promise for further research in the development of new pharmaceuticals or bioactive compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 13373-31-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,3,7 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13373-31:
(7*1)+(6*3)+(5*3)+(4*7)+(3*3)+(2*3)+(1*1)=84
84 % 10 = 4
So 13373-31-4 is a valid CAS Registry Number.
13373-31-4Relevant articles and documents
Synthesis of 3-Amino-5H-pyridoindoles, Carcinogenic γ-Carbolines
Akimoto, Hiroshi,Kawai, Akiyoshi,Nomura,Hiroaki
, p. 123 - 130 (2007/10/02)
The carcinogenic γ-carbolines 3-amino-1,4-dimethyl-5H-pyridoindole (1) and 3-amino-1-methyl-5H-pyridoindole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-γ-carbolines.This was followed by dehydrogenation to the γ-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of γ-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-indoles.
