Cyclohexanesulfonamide, N-methyl-2-oxo-

Base Information

• Chemical Name: Cyclohexanesulfonamide, N-methyl-2-oxo-
• CAS No.: 96355-28-1
• Molecular Formula: C7H13NO3S
• Molecular Weight: 191.251
• DSSTox Substance ID: DTXSID50454630
• Nikkaji Number: J956.295H
• Mol file: 96355-28-1.mol

Synonyms:Cyclohexanesulfonamide, N-methyl-2-oxo-;96355-28-1;DTXSID50454630;N-Methyl-2-oxocyclohexanesulfonamide

Chemical Property of Cyclohexanesulfonamide, N-methyl-2-oxo-

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 191.06161445
• Heavy Atom Count: 12
• Complexity: 265

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNS(=O)(=O)C1CCCCC1=O

Technology Process of Cyclohexanesulfonamide, N-methyl-2-oxo-

There total 2 articles about Cyclohexanesulfonamide, N-methyl-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + N-methylsulfamoyl chloride (10438-96-7) → 2-Oxo-cyclohexanesulfonic acid methylamide (96355-28-1)

Guidance literature:

With triethylamine; In acetonitrile; for 24h; Heating;

DOI:10.1016/S0040-4020(98)00093-3

Reference yield:

N-methylsulfamoyl chloride (10438-96-7) → 2-Oxo-cyclohexanesulfonic acid methylamide (96355-28-1)

Guidance literature:

With hydrogenchloride; triethylamine; Yield given. Multistep reaction; 1.) THF, -40 deg C -> 20 deg C, 2 h;

DOI:10.1055/s-1985-31109

Reference yield: 62.0%

2-Oxo-cyclohexanesulfonic acid methylamide (96355-28-1) → 2-Amino-N-methyl-1-cyclohexensulfonamid (96355-27-0)

Guidance literature:

With ammonium acetate; In ethanol; at 50 ℃; for 2h;

upstream raw materials:

1-(Trimethylsilyloxy)cyclohexene

N-methylsulfamoyl chloride

Downstream raw materials:

2-Amino-N-methyl-1-cyclohexensulfonamid