4-Bromopyridine N-Oxide

Base Information

• Chemical Name: 4-Bromopyridine N-Oxide
• CAS No.: 14248-50-1
• Molecular Formula: C5H4 Br N O
• Molecular Weight: 173.997
• Hs Code.: 2933399090
• Mol file: 14248-50-1.mol

Synonyms:4-Bromopyridine1-oxide; 4-Bromopyridine N-oxide; 4-Bromopyridine, oxide; NSC 111282

Chemical Property of 4-Bromopyridine N-Oxide

Chemical Property:

• Vapor Pressure: 0.000223mmHg at 25°C
• Melting Point: 163℃ (Decomposition)
• Boiling Point: 336.2°Cat760mmHg
• PKA: 0?+-.0.10(Predicted)
• Flash Point: 157.1°C
• PSA: 25.46000
• Density: 1.66g/cm³
• LogP: 1.87760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Dimethyl Sulfoxide, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromopyridine N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromopyridine N-Oxide

There total 9 articles about 4-Bromopyridine N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-bromopyridin (1120-87-2) → 4-bromopyridine-1-oxide (14248-50-1)

Guidance literature:

With dihydrogen peroxide; In acetonitrile; at 80 ℃; for 8h; under 760.051 Torr;

DOI:10.1039/c3cy00963g

Reference yield: 90.0%

4-bromopyridine hydrochloride (19524-06-2) → 4-bromopyridine-1-oxide (14248-50-1)

Guidance literature:

4-bromopyridine hydrochloride; With potassium carbonate; In dichloromethane; for 2h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 66.0%

4-nitraminopyridine N-oxide (1124-33-0) → 4-bromopyridine-1-oxide (14248-50-1)

Guidance literature:

With Acetyl bromide; acetic acid; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.200701023

upstream raw materials:

4-nitraminopyridine N-oxide

Acetyl bromide

4-bromopyridin

hydrogen bromide

Downstream raw materials:

4-bromo-2-cyanopyridine

ethyl 4-bromopyridine-2-carboxylate

4-bromo-2-picolinic acid

2-(4-bromopyridin-2-yl)-4-hydroxy-N-(1-methyl-1-phenylethyl)pyrimidine-5-carboxamide

Refernces

• 1、 Kidd,Watson. "Magnetic susceptibility study of copper(II) halide complexes with 4-substituted pyridine N-oxides". . p. 1886 - 1891. Retrieved 1969.
• 2、 Breinbauer, Rolf,Doler, Carina,Fuchs, Elisabeth,Grabner, Gernot F.,Mayer, Nicole,Melcher, Michaela-Christina,Migglautsch, Anna K.,Romauch, Matthias,Schweiger, Martina,Zechner, Rudolf,Zimmermann, Robert. "Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)". supporting information. . Retrieved 2020/07/13.
• 3、 Harisha, Mysore Bhyrappa,Nagaraj, Muthupandi,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai. "Base free regioselective synthesis of α-triazolylazine derivatives". . p. 58118 - 58124. Retrieved 2016/07/06.