METHYL 1-METHYLPYRROLE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1-METHYLPYRROLE-2-CARBOXYLATE
• CAS No.: 37619-24-2
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933990090
• Mol file: 37619-24-2.mol

Synonyms:Pyrrole-2-carboxylicacid, 1-methyl-, methyl ester (6CI,7CI);1-Methyl-1H-pyrrole-2-carboxylic acidmethyl ester;1-Methyl-2-pyrrolecarboxylic acid methyl ester;2-(Methoxycarbonyl)-1-methylpyrrole;2-Methoxycarbonyl-N-methylpyrrole;Methyl1-methyl-1H-pyrrole-2-carboxylate;Methyl 1-methylpyrrole-2-carboxylate;MethylN-methylpyrrole-2-carboxylate;methyl 1-methylpyrrole-2-carboxylate;

Chemical Property of METHYL 1-METHYLPYRROLE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.26mmHg at 25°C
• Melting Point: 80 °C (sublm)(Press: 0.2 Torr)
• Refractive Index: 1.5220
• Boiling Point: 204.7 °C at 760 mmHg
• PKA: -7.04±0.70(Predicted)
• Flash Point: 77.6 °C
• PSA: 31.23000
• Density: 1.07 g/cm³
• LogP: 0.81170
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-Methylpyrrole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 1-methylpyrrole-2-carboxylate is used as chemical and organic Intermediates.

Technology Process of METHYL 1-METHYLPYRROLE-2-CARBOXYLATE

There total 19 articles about METHYL 1-METHYLPYRROLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl Pyrrole-2-carboxylate (1193-62-0) + methyl iodide (74-88-4) → methyl N-methylpyrrole-2-carboxylate (37619-24-2)

Guidance literature:

methyl Pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/acs.orglett.5b01024

Reference yield: 90.4%

methyl Pyrrole-2-carboxylate (1193-62-0) + carbonic acid dimethyl ester (616-38-6) → methyl N-methylpyrrole-2-carboxylate (37619-24-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 90 - 92 ℃; for 23h;

DOI:10.1021/op900256t

Reference yield: 90.0%

1-Methyl-2-pyrrolecarboxylic acid (6973-60-0) + methyl iodide (74-88-4) → methyl N-methylpyrrole-2-carboxylate (37619-24-2)

Guidance literature:

With sodium carbonate; In acetone; for 18h; Heating;

DOI:10.1002/jps.2600781106

upstream raw materials:

diazomethane

1-Methyl-2-pyrrolecarboxylic acid

methyl Pyrrole-2-carboxylate

methyl iodide

Downstream raw materials:

methyl 4-formyl-1-methyl-1H-pyrrole-2-carboxylate

1-Methyl-2-pyrrolecarboxylic acid

1-(1-methyl-1H-pyrrol-2-yl)pent-4-en-1-one

1-methyl-2-methoxycarbonyl-4-chloropyrrole