Chol-5-ene-3,24-diol, (3beta)-

Base Information

• Chemical Name: Chol-5-ene-3,24-diol, (3beta)-
• CAS No.: 54668-67-6
• Molecular Formula: C₂₄H₄₀O₂
• Molecular Weight: 360.58
• Mol file: 54668-67-6.mol

Synonyms:5-Cholene-3b,24-diol

Chemical Property of Chol-5-ene-3,24-diol, (3beta)-

Chemical Property:

• Vapor Pressure: 1.88E-11mmHg at 25°C
• Boiling Point: 485.2°C at 760 mmHg
• Flash Point: 208.8°C
• PSA: 40.46000
• Density: 1.06g/cm³
• LogP: 5.33490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Chol-5-ene-3,24-diol, (3beta)-

There total 17 articles about Chol-5-ene-3,24-diol, (3beta)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 5-cholenoate (20231-57-6) → 3β,24-dihydroxychol-5-ene (54668-67-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1016/S0968-0896(97)00010-2

Reference yield: 61.0%

3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-ol (66414-43-5) → 3β,24-dihydroxychol-5-ene (54668-67-6)

Guidance literature:

With acetic acid; In tetrahydrofuran; at 65 ℃;

DOI:10.1016/S0968-0896(97)00085-0

Reference yield: 55.0%

Diazo-acetic acid (S)-4-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-pentyl ester → Formic acid (S)-4-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-pentyl ester (105079-38-7) + Cyclohexyl-acetic acid (S)-4-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-pentyl ester (105079-37-6) + (3S,8S,9S,10R,13R,14S,17R)-17-((S)-4-Hydroxy-1-methyl-butyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (54668-67-6)

Guidance literature:

In cyclohexane; for 0.166667h; Irradiation;

DOI:10.1248/cpb.34.935

upstream raw materials:

methyl 5-cholenoate

3β-hydroxy-cholene-(5)-thioic acid-(24)-S-ethyl ester

3β-(O)-acetoxychol-5-en-24-ol

methyl 3β-acetoxychol-5-en-24-oate

Downstream raw materials:

1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

1α,25-dihydroxy-26,27-diethylvitamin D₃

1α,25-dihydroxy-26,27-dimethylvitamin D₃

1α-dihydroxy-26,27-dimethylvitamin D₃

Refernces

• 1、 Deno,Meyer. "". . p. 3383. Retrieved 1979.
• 2、 Morisaki, Naoko,Kobayashi, Hisayoshi,Yamamura, Yumiko,Morisaki, Masuo,Nagasawa, Kazuo,Hashimoto, Yuichi. "Coordination of sodium cation to an oxygen function and olefinic double bond to form molecular adduct ion in fast atom bombardment mass spectrometry". . p. 935 - 940. Retrieved 2007/10/03.