1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

Base Information

Chemical Name:1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene
CAS No.:115567-36-7
Molecular Formula:C₃₅H₅₄O₇S
Molecular Weight:618.876
Hs Code.:

Synonyms:

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Chemical Property of 1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

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Technology Process of 1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

There total 8 articles about 1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 106372-41-2
1α,3β-bis(methoxymethoxy)chol-5-en-24-ol

: 98-59-9
p-toluenesulfonyl chloride

: 115567-36-7
1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

Guidance literature:: With pyridine; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.36.2303

Reference yield:

: 5255-17-4
3β-hydroxy-5-cholenoic acid

: 115567-36-7
1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

Guidance literature:: Multi-step reaction with 8 steps

1: lithium aluminum hydride / tetrahydrofuran / 18 h / 60 °C

2: dichlorodicyanobenzoquinone / dioxane / 15 h / Ambient temperature

3: p-toluenesulfonic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 72 percent / sodium hydroxide, hydrogen peroxide / methanol; H₂O / 1.5 h / Ambient temperature

5: lithium / liquid ammonia; tetrahydrofuran / 1.5 h / -78 °C

6: N,N-diethylcyclohexylamine / dioxane / 1.) 50 deg C, 6 h; 2.) 80 deg C, 2 h

7: aq. HCl; tetrahydrofuran; methanol / Ambient temperature

8: 73 percent / pyridine / 0.5 h / 0 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; diethyl-cyclohexyl-amine; dihydrogen peroxide; lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; dichloromethane; ammonia; water;
DOI:10.1248/cpb.36.2303

Reference yield:

: 54668-67-6
3β,24-dihydroxychol-5-ene

: 115567-36-7
1α,3β-bis(methoxymethoxy)-24-p-toluenesulfonyloxychol-5-ene

Guidance literature:: Multi-step reaction with 7 steps

1: dichlorodicyanobenzoquinone / dioxane / 15 h / Ambient temperature

2: p-toluenesulfonic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 72 percent / sodium hydroxide, hydrogen peroxide / methanol; H₂O / 1.5 h / Ambient temperature

4: lithium / liquid ammonia; tetrahydrofuran / 1.5 h / -78 °C

5: N,N-diethylcyclohexylamine / dioxane / 1.) 50 deg C, 6 h; 2.) 80 deg C, 2 h

6: aq. HCl; tetrahydrofuran; methanol / Ambient temperature

7: 73 percent / pyridine / 0.5 h / 0 °C

With pyridine; sodium hydroxide; diethyl-cyclohexyl-amine; dihydrogen peroxide; lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; dichloromethane; ammonia; water;
DOI:10.1248/cpb.36.2303