Cetefloxacin

Base Information

• Chemical Name: Cetefloxacin
• CAS No.: 141725-88-4
• Molecular Formula: C20H16 F3 N3 O3
• Molecular Weight: 403.3545
• Mol file: 141725-88-4.mol

Synonyms:3-Quinolinecarboxylicacid, 7-(3-amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-,(2S-trans)-; Cetefloxacin; E 4868

Chemical Property of Cetefloxacin

Chemical Property:

• Vapor Pressure: 7.34E-15mmHg at 25°C
• Boiling Point: 592°Cat760mmHg
• Flash Point: 311.8°C
• PSA: 88.56000
• Density: 1.502g/cm³
• LogP: 3.40730

Purity/Quality:

95-99% ^*data from raw suppliers

CETEFLOXACIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cetefloxacin

There total 1 articles about Cetefloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid (103995-01-3) + (2S,3R)-3-amino-2-methylazetidine dihydrochloride → cetefloxacin (141725-88-4)

Guidance literature:

With pyridine; triethylamine; for 3h; Heating;

DOI:10.1021/jm00007a017

Reference yield:

cetefloxacin (141725-88-4) → 7-[(2S,3R)-3-((S)-2-Amino-propionylamino)-2-methyl-azetidin-1-yl]-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / 8 h / Ambient temperature

2: H₂ / 10percent Pd/C / dimethylformamide / 24 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm00007a017

Reference yield:

cetefloxacin (141725-88-4) → 7-[(2S,3R)-3-((R)-2-Amino-propionylamino)-2-methyl-azetidin-1-yl]-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / 8 h / Ambient temperature

2: H₂ / 10percent Pd/C / dimethylformamide / 24 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm00007a017

upstream raw materials:

6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid

Refernces