103995-01-3

Basic information

• Product Name: 1-(2,4-DIFLUOROPHENYL)-6,7-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 1-(2,4-DIFLUOROPHENYL)-6,7-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID;1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxoquinolin-3-carboxylic acid;1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid;1-(2，4-DIFLUORO-PHENYL)-6，7-DIFLUORO-4-OXO-1，4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
• CAS NO: 103995-01-3
• Molecular Formula: C₁₆H₇F₄NO₃
• Molecular Weight: 337.23
• EINECS: 406-710-0
• Mol File: 103995-01-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 472.2°Cat760mmHg
• Flash Point: 239.4°C
• Appearance: /
• Density: 1.618g/cm³
• Vapor Pressure: 1.02E-09mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 1-(2,4-DIFLUOROPHENYL)-6,7-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DIFLUOROPHENYL)-6,7-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID(103995-01-3)
• EPA Substance Registry System: 1-(2,4-DIFLUOROPHENYL)-6,7-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID(103995-01-3)

Safety Data

• Hazardous Substances Data: 103995-01-3(Hazardous Substances Data)

Usage

Uses

1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is an intermediate used to prepare hydrazinoquinolones and azetidinylquinolinones derivatives as antibacterial agents.

InChI:InChI=1/C16H7F4NO3/c17-7-1-2-13(12(20)3-7)21-6-9(16(23)24)15(22)8-4-10(18)11(19)5-14(8)21/h1-6H,(H,23,24)

Upstream product

• 129322-83-4 2',4',5'-trifluoroacetophenone 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 367-23-7 1,2,4-trifluorobenzene 
• 108115-67-9 ethyl 3-(2,4-difluoroanilino)-2-(2,4,5-trifluorobenzoyl)acrylate 
• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 367-25-9 2,4-difluorophenylamine 
• 108138-17-6 6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 141725-88-4 cetefloxacin 
• 174358-28-2 PD 161654 
• 108138-27-8 A 57531 
• 145122-52-7 1-(2,4-difluorophenyl)-6-fluoro-7-(3,3-dimethylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride 
• 138808-67-0 1-(2,4-Difluoro-phenyl)-6-fluoro-7-((1S,4S)-5-methyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 

Relevant articles and documents

Baylis-Hillman route to several quinolone antibiotic intermediates

Treatment of methyl propiolate and 2,4,5-trifluoro-, 2-fluoro-, 2-fluoro-5-methoxy- or 2,3,4,5-tetrafluorobenzaldehydes with a ZrCl 4/Bu4NI combination induces an aldol reaction to furnish β-iodo-α-(hydroxyalkyl)acrylates. These can be used for the preparation of several quinolone intermediates, 1-substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acids and 9,10-difluoro-3-methyl-2,3- dihydro-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid through the oxidation, amination and hydrolysis reactions. Georg Thieme Verlag Stuttgart.

Synthesis, Antibacterial Activities, and Pharmacological Properties of Enantiomers of Temafloxacin Hydrochloride

Temafloxacin hydrochloride is a potent member of the 4-pyridone-3-carboxylic acid class of antibacterial agents and is currently under clinical development as a broad-spectrum antimicrobial agent.It is a racemate having a chiral center at the C3 of the 7-piperazin-1-yl group.The two enantiomers were synthesized and tested for their antibacterial activities.Although no difference in in vitro antibacterial activities was observed, a minor difference in in vivo antibacterial activities was observed.However, they both exhibited similar pharmacological profiles.