2-Propenoic acid, 2-hydroxy-3-[2-nitro-3-(phenylmethoxy)phenyl]-, ethyl ester, potassium salt

Base Information

• Chemical Name: 2-Propenoic acid, 2-hydroxy-3-[2-nitro-3-(phenylmethoxy)phenyl]-, ethyl ester, potassium salt
• CAS No.: 96564-49-7
• Molecular Formula: C18H17NO6.K
• Molecular Weight: 381.426
• Mol file: 96564-49-7.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 2-hydroxy-3-[2-nitro-3-(phenylmethoxy)phenyl]-, ethyl ester, potassium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 2-hydroxy-3-[2-nitro-3-(phenylmethoxy)phenyl]-, ethyl ester, potassium salt

There total 3 articles about 2-Propenoic acid, 2-hydroxy-3-[2-nitro-3-(phenylmethoxy)phenyl]-, ethyl ester, potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(benzyloxy)-3-methyl-2-nitrobenzene (61535-21-5) + oxalic acid diethyl ester (95-92-1) → ethyl 3-(3-benzyloxy-2-nitrophenyl)-pyruvate, potassium salt (96564-49-7)

Guidance literature:

With potassium ethoxide; In diethyl ether; for 20h; Heating;

Reference yield:

3-methyl-2-nitrophenol (4920-77-8) → C18H16NO6(1-)*K(1+) (96564-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 2.5 h / 75 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; tert-butyl methyl ether / 24 h / Inert atmosphere; Heating

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; tert-butyl methyl ether; acetonitrile;

DOI:10.1271/bbb.100124

Reference yield:

1-(benzyloxy)-3-methyl-2-nitrobenzene (61535-21-5) + oxalic acid diethyl ester (95-92-1) → C18H16NO6(1-)*K(1+) (96564-49-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; tert-butyl methyl ether; for 24h; Inert atmosphere; Heating;

DOI:10.1271/bbb.100124

upstream raw materials:

1-(benzyloxy)-3-methyl-2-nitrobenzene

oxalic acid diethyl ester

3-methyl-2-nitrophenol

Downstream raw materials:

C₂₄H₁₉NO₅

7-benzyloxy-2-indolinone

3-benzyloxy-2-nitrophenyl-acetic acid

(3-benzyloxy-2-nitro-phenyl)-pyruvic acid