61535-21-5

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Benzyloxy-3-methyl-2-nitrobenzene is used as an intermediate in the multi-step preparation of 7-hydroxy-oxindole-3-acetic acid, which is a significant compound in the pharmaceutical industry. The synthesis of such molecules is crucial for the development of new drugs and therapeutic agents.
Used in Chemical Research:
As a substituted nitrobenzene, 1-Benzyloxy-3-methyl-2-nitrobenzene can be utilized in various chemical research applications, including the study of reaction mechanisms, the development of new synthetic methods, and the exploration of novel chemical properties.
Used in the Synthesis of Dyes and Pigments:
1-BENZYLOXY-3-METHYL-2-NITROBENZENE 98 may also find applications in the synthesis of dyes and pigments due to its structural features, which can contribute to the color and stability of these products.
Used in the Production of Advanced Materials:
1-Benzyloxy-3-methyl-2-nitrobenzene can be employed in the development of advanced materials, such as polymers and composites, where its unique structural properties can enhance the performance of these materials in various applications.

InChI:InChI=1/C14H13NO3/c1-11-6-5-9-13(14(11)15(16)17)18-10-12-7-3-2-4-8-12/h2-9H,10H2,1H3

Upstream product

• 4920-77-8 3-methyl-2-nitrophenol 
• 100-39-0 benzyl bromide 
• 584-08-7 potassium carbonate 
• 4560-41-2 2-benzyloxynitrobenzene 
• 2181-42-2 trimethylsulphonium iodide 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 110655-06-6 (3-benzyloxy-2-nitro-phenyl)-pyruvic acid 
• 20289-27-4 7-benzyloxyindole 
• 84639-06-5 7-benzyloxyindole-2-carboxylic acid ethyl ester 
• 883107-58-2 2-(benzyloxy)-6-methylbenzenamine 
• 6855-54-5 3-benzyloxy-2-nitrophenyl-acetic acid 
• 928014-67-9 2-(benzyloxy)-4-bromo-6-methylbenzenamine 
• 96564-49-7 C₁₈H₁₆NO₆^(1-)*K⁽¹⁺⁾ 
• 74864-81-6 7-benzyloxy-2-indolinone 
• 110655-09-9 C₂₄H₁₉NO₅ 
• 84639-84-9 7-hydroxy-1H-indole-2-carboxylic acid 
• 84638-99-3 methyl-3-(N-<2-oxo-2-(2-ethoxycarbinol-7-hydroxyindole-4-yl)-ethyl>-N-benzylamino)-butyrate, hydrochloride 
• 84638-81-3 methyl 4-(2-tert.-butylamino-1-hydroxyethyl)-7-hydroxyindole-2-carboxylate, hydrochloride 
• 84639-35-0 butyl 7-benzyloxyindole-2-carboxylate 
• 96564-48-6 methyl 7-(benzyloxy)-1H-indole-2-carboxylate 

Relevant academic research and scientific papers

BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS

The present invention is directed to benzocyclobutane derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.

The mechanism of the ortho-methylation of nitrobenzenes by dimethylsulfonium methylide

Nitrobenzenes carrying an ortho substituent are selectively methylated at the free ortho position by reaction with dimethylsulfonium methylide. The importance of the ortho substituent is demonstrated by the failure of the methylation of nitrobenzene and 3- and 4-nitroanisole. This is explained by the out-of-plane geometry of the nitro group in the ortho-substituted derivative, which enables a specific interaction between the ylide and the nitro group favourable for attack of the methylide C atom at the neighbouring free ortho position. As shown by appropriate deuterium-labelling studies, the addition is followed by an E1-like β-elimination with displacement of dimethyl sulfide and subsequent protonation of the elimination product. The nucleophilic ortho-methylation of 2-nitroanisole by dimethylsulfonium methylide is explained by a reaction sequence including intermediates A to D. Copyright

Antioxidative activities of oxindole-3-acetic acid derivatives from supersweet corn powder

The components contributing to the antioxidative activity of supersweet corn powder (SSCP), which is commonly used in corn soup and snacks in Japan, were clarified and the effects investigated. 7-(0-/3-Glucosy-loxy)oxindole-3- acetic acid (GOA) was found

Cytokine inhibitors

Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclos

Cytokine inhibitors

Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

An efficient and practical synthesis of N,N-diethyl-7-indolyloxyacetamide via 7-hydroxyindole

An efficient and practical synthesis of N, N-diethyl-7-indolyloxyacetamide (1) from 3-hydroxy-2-nitrotoluene (4) via 7-hydroxyindole (2) is described. Treatment of 3-benzyloxy-2-nitrotoluene (5) obtained from 4 with DMF dimethyl acetal and pyrrolidine afforded the (E)-2-nitro-β-pyrrolidinostyrene 6, which can be readily converted into the 2-nitrophenylacetaldehyde semicarbazone 7 without isolation of 6. Hydrogenation of 7 over Pd/C, followed by reaction of the resulting 2 with 2-chloro-N, N-diethylacetamide produced 1 in good yield.

Chemical compounds

Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.

5-HT4 receptor agonists

Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT4 receptors. STR1 wherein Ak is a C3 -C6 alkyl group, and R is a C2 -C6 alkyl group, a C3 -C6 alkenyl group, a C3 -C6 alkynyl group, a C3 -C7 cycloalkyl group or a C3 -C6 cycloalkylmethyl group.