methyl 2-methyl-N-oxoalaninate

Base Information

• Chemical Name: methyl 2-methyl-N-oxoalaninate
• CAS No.: 17746-46-2
• Molecular Formula: C₅H₉NO₃
• Molecular Weight: 131.131
• Mol file: 17746-46-2.mol

Synonyms:Propionicacid, 2-methyl-2-nitroso-, methyl ester (8CI); 2-Methyl-2-nitrosopropionic acidmethyl ester

Chemical Property of methyl 2-methyl-N-oxoalaninate

Chemical Property:

• Vapor Pressure: 8.45mmHg at 25°C
• Boiling Point: 133.5°Cat760mmHg
• Flash Point: 33.3°C
• Density: 1.08g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-N-oxoalaninate

There total 4 articles about methyl 2-methyl-N-oxoalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-2-methylpropionic acid methyl ester (13257-67-5) → α-nitrosoisobutyrate (17746-46-2,6144-15-6)

Guidance literature:

With formic acid; acetic anhydride; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield: 47.3%

methyl 2-(N,N-dimethoxyamino)-2-methylpropionate (76664-33-0) → α-nitrosoisobutyrate (17746-46-2,6144-15-6)

Guidance literature:

With Dowex 50 W x 12 (H⁺); In methanol; for 1h;

DOI:10.1007/BF01094639

Reference yield:

methyl ester of α-(N-methoxy-N-ethoxyamino)isobutyric acid (79055-32-6) → α-nitrosoisobutyrate (17746-46-2,6144-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.6 percent / Et₃N*HCl / 1 h / Heating

2: 47.3 percent / Dowex 50 W x 12 (H⁺) / methanol / 1 h

With Dowex 50 W x 12 (H⁺); triethylamine hydrochloride; In methanol;

DOI:10.1007/BF01094639

upstream raw materials:

methyl 2-(N,N-dimethoxyamino)-2-methylpropionate

dimethyl 2,2'-hydrazinobisisobutyrate

methyl ester of α-(N-methoxy-N-ethoxyamino)isobutyric acid

2-amino-2-methylpropionic acid methyl ester

Downstream raw materials:

2-carbomethoxy-2-methylethyl isocyanide

Refernces

• 1、 Rudchenko, V. F.,Shtamburg, V. G.,Pleshkova, A. P.,Nasibov, Sh. S.,Chervin, I. I.,Kostyanovskii, R. G.. "GENINAL SYSTEM. 17. ACID-CATALYZED REACTIONS OF N,N-DIALKOXYAMINES". . p. 2100 - 2109. Retrieved 2007/10/02.