Tetomilast

Base Information

Chemical Name:Tetomilast
CAS No.:145739-56-6
Molecular Formula:C19H18 N2 O4 S
Molecular Weight:370.429
Hs Code.:2934100090
UNII:S6RXB5KF56
DSSTox Substance ID:DTXSID00163149
Nikkaji Number:J634.529H
Wikidata:Q27095582
NCI Thesaurus Code:C90922
Pharos Ligand ID:T7HFRLMADXCB
Metabolomics Workbench ID:149443
ChEMBL ID:CHEMBL332750
Mol file:145739-56-6.mol

Synonyms:6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)-pyridine-2-carboxylic acid;OPC 6535;OPC-6535;OPC6535;tetomilast

Suppliers and Price of Tetomilast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+%
25g
$ 7808.00

Crysdot
6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+%
10g
$ 4683.00

Crysdot
6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+%
5g
$ 3120.00

Crysdot
6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+%
1g
$ 1297.00

Chemenu
6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)picolinicacid 95%
1g
$ 1222.00

American Custom Chemicals Corporation
6-[2-(3,4-DIETHOXYPHENYL)-1,3-THIAZOL-4-YL]PYRIDINE-2-CARBOXYLIC ACID 95.00%
5MG
$ 505.42

Alichem
6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid
25g
$ 8522.40

Total 45 raw suppliers

Chemical Property of Tetomilast

Chemical Property:

Vapor Pressure:3.53E-15mmHg at 25°C
Boiling Point:598.6°Cat760mmHg
PKA:3.28±0.10(Predicted)
Flash Point:315.8°C
PSA：109.78000
Density:1.279g/cm³
LogP:4.36770
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:370.09872823
Heavy Atom Count:26
Complexity:467

Purity/Quality:

99% ^*data from raw suppliers

6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC1=C(C=C(C=C1)C2=NC(=CS2)C3=NC(=CC=C3)C(=O)O)OCC
Recent ClinicalTrials:A Dose-finding Study of OPC-6535 in Patients With Active Ulcerative Colitis
Recent EU Clinical Trials:A Phase 3, Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-arm Study of the Efficacy and Safety of OPC-6535 Tablets in the Treatment of Subjects with Active Ulcerative Colitis

Technology Process of Tetomilast

There total 8 articles about Tetomilast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 145739-56-6
6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid

Guidance literature:: Purification / work up;

Reference yield: 91.3%

: 160322-91-8
methyl 6-<2-(3,4-diethoxyphenyl)thiazol-4-yl>pyridine-2-carboxylate

: 145739-56-6
6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 4h; Heating;
DOI:10.1021/jm00002a017

Reference yield: 78.4%

: 298692-34-9
2-(2-chloroacetyl)-6-pyridine carboxylic acid

: 60759-00-4
3,4-diethoxybenzthioamide

: 145739-56-6
6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid

Guidance literature:: 2-(2-chloroacetyl)-6-pyridine carboxylic acid; 3,4-diethoxybenzthioamide; In 1,2-dimethoxyethane; water; for 2h; Heating / reflux;

With potassium hydroxide; In water; Product distribution / selectivity;