60759-00-4

Basic information

• Product Name: BenzenecarbothioaMide, 3,4-diethoxy-
• Synonyms: BenzenecarbothioaMide, 3,4-diethoxy-;3,4-Diethoxybenzothioamide
• CAS NO: 60759-00-4
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.3073
• EINECS: -0
• Mol File: 60759-00-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzenecarbothioaMide, 3,4-diethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzenecarbothioaMide, 3,4-diethoxy-(60759-00-4)
• EPA Substance Registry System: BenzenecarbothioaMide, 3,4-diethoxy-(60759-00-4)

Safety Data

• Hazardous Substances Data: 60759-00-4(Hazardous Substances Data)

Upstream product

• 2050-46-6 1,2-diethoxybenzene 
• 333-20-0 potassium thioacyanate 
• 60758-87-4 3,4-diethoxybenzonitrile 
• 62-55-5 thioacetamide 

Downstream Products

• 160322-96-3 4-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-benzoic acid methyl ester 
• 160322-92-9 3-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-benzoic acid methyl ester 
• 160322-94-1 5-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-furan-2-carboxylic acid methyl ester 
• 160322-95-2 5-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-thiophene-2-carboxylic acid methyl ester 
• 160322-91-8 methyl 6-<2-(3,4-diethoxyphenyl)thiazol-4-yl>pyridine-2-carboxylate 
• 870001-07-3 3-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]propionic acid 
• 870001-05-1 2-(3,4-diethoxyphenyl)-4-chloromethylthiazole 
• 145739-56-6 6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid 
• 160322-93-0 2-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-benzoic acid methyl ester 
• 155468-05-6 2-(3,4-diethoxyphenyl)-4-(4-carboxy-6-ethoxycarbonyl-pyridin-2-yl)thiazole 
• 155468-04-5 2-(3,4-diethoxyphenyl)-4-[6-(1,2-dihydroxyethyl)-pyridin-2-yl]thiazole 

Relevant articles and documents

A practical synthesis of 3,4-diethoxybenzthioamide based on Friedel-Crafts reaction with potassium thiocyanate in methanesulfonic acid.

The synthesis of 3,4-diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel-Crafts reaction of 1,2-diethoxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature.

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4- diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure- activity relationships of these compounds are reported herein.