60759-00-4

Upstream product

• 2050-46-6 1,2-diethoxybenzene 
• 333-20-0 potassium thioacyanate 
• 60758-87-4 3,4-diethoxybenzonitrile 
• 62-55-5 thioacetamide 

Downstream Products

• 160322-96-3 4-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-benzoic acid methyl ester 
• 160322-92-9 3-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-benzoic acid methyl ester 
• 160322-94-1 5-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-furan-2-carboxylic acid methyl ester 
• 160322-95-2 5-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-thiophene-2-carboxylic acid methyl ester 
• 160322-91-8 methyl 6-<2-(3,4-diethoxyphenyl)thiazol-4-yl>pyridine-2-carboxylate 
• 870001-07-3 3-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]propionic acid 
• 870001-05-1 2-(3,4-diethoxyphenyl)-4-chloromethylthiazole 
• 155468-05-6 2-(3,4-diethoxyphenyl)-4-(4-carboxy-6-ethoxycarbonyl-pyridin-2-yl)thiazole 
• 155468-04-5 2-(3,4-diethoxyphenyl)-4-[6-(1,2-dihydroxyethyl)-pyridin-2-yl]thiazole 
• 155468-01-2 2-(3,4-diethoxyphenyl)-4-[6-(1,2,4-triazol-1-yl)-pyridin-2-yl]thiazole 
• 155468-00-1 2-(3,4-diethoxyphenyl)-4-(6-morpholino-pyridin-2-yl)thiazole hydrochloride 

Relevant academic research and scientific papers

A practical synthesis of 3,4-diethoxybenzthioamide based on Friedel-Crafts reaction with potassium thiocyanate in methanesulfonic acid.

The synthesis of 3,4-diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel-Crafts reaction of 1,2-diethoxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature.

Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1is

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4- diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure- activity relationships of these compounds are reported herein.